Catecholaminergic-to-cholinergic transition of sympathetic nerve fibers is stimulated under healthy but not under inflammatory arthritic conditions

Brain, Behavior, and Immunity
Hubert StanglRainer H Straub

Abstract

Density of sympathetic nerve fibers decreases in inflamed arthritic tissue tested by immunoreactivity towards tyrosine-hydroxylase (TH, catecholaminergic key enzyme). Since sympathetic nerve fibers may change phenotype from catecholaminergic to cholinergic (example: sweat glands), loss of nerve fibers may relate to undetectable TH. We aimed to investigate possible catecholaminergic-to-cholinergic transition of sympathetic nerve fibers in synovial tissue of animals with arthritis, and patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and we wanted to find a possible transition factor. Nerve fibers were detected by immunofluorescence towards TH (catecholaminergic) and vesicular acetylcholine transporter (cholinergic). Co-culture experiments with sympathetic ganglia and lymphocytes or osteoclast progenitors were designed to find stimulators of catecholaminergic-to-cholinergic transition (including gene expression profiling). In mouse joints, an increased density of cholinergic relative to catecholaminergic nerve fibers appeared towards day 35 after immunization, but most nerve fibers were located in healthy joint-adjacent skin or muscle and almost none in inflamed synovial tissue. In humans, cholinergic fibers are m...Continue Reading

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Citations

May 27, 2017·Journal of Internal Medicine·F A KoopmanP P Tak
Apr 25, 2018·Zeitschrift für Rheumatologie·G SchettR H Straub
Apr 15, 2018·Zeitschrift für Rheumatologie·H-G SchaibleR H Straub
Jan 20, 2018·Physiological Reviews·Robert Dantzer
Feb 21, 2021·Osteoarthritis and Cartilage·M LauwersC Wen

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