PMID: 15367888Sep 16, 2004Paper

Catecholamines and 5-hydroxytryptamine in tissues of the rabbit exocrine pancreas

Pancreas
Eunyoung YiJeffrey A Love

Abstract

Norepinephrine (NE), dopamine (DA), epinephrine (Epi), and 5-hydroxytryptamine (5-HT) all modulate pancreatic exocrine secretion, yet their concentrations in specific tissues of the exocrine pancreas are unknown. Concentrations of catecholamines and 5-HT in rabbit pancreatic ganglia, acini, ducts and ampullae, and arteries and veins were measured using HPLC. Concentrations of NE in ganglia from the head/neck region were significantly higher than those from the body (1620 +/- 220 vs. 778 +/- 179 pmol/mg protein). Acini contained little NE, DA, or 5-HT (9 +/- 2, 0.9 +/- 0.2, 13 +/- 5 pmol/mg protein). Ducts and ampullae contained NE (314 +/- 74 and 156 +/- 24 pmol/mg protein), DA (43 +/- 14 and 13 +/- 4 pmol/mg protein), Epi (63 +/- 29 and 39 +/- 6 pmol/mg protein), and 5-HT (696 +/- 151 and 3563 +/- 288 pmol/mg protein). Arteries and veins contained the highest concentrations of NE (1962 +/- 463 and 736 +/- 80 pmol/mg protein, respectively). Pancreatic ganglia and blood vessels, rather than acini, are the main sites of noradrenergic sympathetic innervation of the rabbit exocrine pancreas. These nerves preferentially target ganglionic transmission in the head/neck versus the body. Serotonergic nerves provide little or no innervat...Continue Reading

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Citations

Aug 12, 2005·Current Opinion in Gastroenterology·Marc D Noble, Rodger A Liddle
Nov 23, 2006·Autonomic Neuroscience : Basic & Clinical·Jeffrey A LoveTina G Smith
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Eunyoung YiJeffrey A Love
Aug 30, 2005·Autonomic Neuroscience : Basic & Clinical·Eunyoung Yi, Jeffrey A Love
May 17, 2005·Autonomic Neuroscience : Basic & Clinical·Eunyoung Yi, Jeffrey A Love
Nov 23, 2017·Biomedical Chromatography : BMC·Joachim NaglerKarl-Werner Schramm
Mar 8, 2019·Frontiers in Neuroscience·Wenjing LiLei Sha
May 15, 2021·Frontiers in Endocrinology·Madina Makhmutova, Alejandro Caicedo
Aug 7, 2021·Frontiers in Neuroanatomy·Battuvshin LkhagvasurenYu-Min Kuo

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