PMID: 9194572May 27, 1997Paper

Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney

Biochimica Et Biophysica Acta
M Manteuffel-CymborowskaB Grzelakowska-Sztabert

Abstract

Catecholamine depletion, evoked by reserpine, dramatically impaired (5-fold) the testosterone-induced increase of ornithine decarboxylase (ODC) activity in female mouse kidney. However, reserpine did not prevent kidney hypertrophy evoked by testosterone. This is evidenced by the activity of sensitive, biochemical markers of renal hypertrophy, namely arginase and ornithine aminotransferase (OAT), that responded with the increase and decrease of activities to testosterone treatment, respectively. Arginine and ornithine, substrates and/or products of marker enzymes, showed a striking homeostasis as their level was not affected by testosterone and reserpine, and only slightly by DFMO. Northern blot analysis revealed that the ODC mRNA level, that was increased 10-fold by testosterone, was decreased 2-fold in catecholamine-depleted hypertrophic kidney. Thus, ODC transcript level, lowered by reserpine, correlated partially with an attenuated response of ODC activity to testosterone. This was in contrast to DFMO, which inhibited ODC activity, but significantly increased its mRNA content. It is concluded that catecholamines could be involved together with testosterone in regulation of the ODC gene expression in mouse kidney.

References

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Citations

Jan 16, 2003·Biochimica Et Biophysica Acta·Magdalena DudkowskaMałgorzata Manteuffel-Cymborowska
Aug 6, 2008·The British Journal of Nutrition·Gabrielle VenturaChristophe Moinard
Jul 28, 2004·Biochimica Et Biophysica Acta·Agnieszka StachurskaBarbara Grzelakowska-Sztabert
Mar 21, 2007·Biochemical Society Transactions·B Grzelakowska-SztabertM Manteuffel-Cymborowska
Apr 4, 2021·Genes·Jeremy W ProkopAndré S Bachmann

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