Catecholamines in coronary sinus and peripheral plasma during pacing-induced angina in man

Circulation
L SchwartzN M Hussain

Abstract

We measured aortic and coronary sinus dopamine (DA), epinephrine (E), and norepinephrine (NE) in eight patients with cardiac ischemia (I) and eight control subjects (C). Samples were taken at rest (73 +/- 3 beats/min in C and 68 +/- 3 beats/min in I) and during coronary sinus pacing to peak rates (144 +/- 4 beats/min in C and 136 +/- 6 beats/min in I). Arterial NE was higher in the ischemic patients at rest (254 +/- 25 pg/ml in C and 324 +/- 21 in I; p less than 0.05). There were no differences in arterial E and DA. Neither pacing nor angina affected peripheral catecholamine concentrations. Resting myocardial NE flux was similar for both groups. With pacing, coronary sinus flow and net myocardial NE release increased significantly in both groups. The maximum relative increase in net myocardial NE release was less in the ischemic patients than in the controls (575 +/- 145% in C and 255 +/- 40% in I; p less than 0.05). Thus, angina induced by pacing does not augment peripheral sympathetic activity. Furthermore, pacing-induced angina appears to be associated with a decrease in cardiac sympathetic tone compared with that found in paced controls.

References

Sep 1, 1977·Clinical and Experimental Pharmacology & Physiology·J Staszewska-Barczak, G J Dusting
Nov 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D CousineauM Bourassa
Nov 1, 1977·Journal of Clinical Pathology·S C Sharma
Nov 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J B HalterD Porte
Jun 1, 1976·Journal of Applied Physiology·H GalboJ Hilsted
May 1, 1975·The American Journal of Physiology·M KumadaK Sagawa
Nov 15, 1969·Lancet·L McDonaldN Restieaux
May 1, 1973·British Medical Bulletin·L L Iversen
May 1, 1972·The American Journal of Physiology·J A Quest, G L Gebber
Apr 1, 1973·Canadian Journal of Physiology and Pharmacology·N YamaguchiR Nadeau
Aug 1, 1971·The American Journal of Physiology·C H Hockman, J Talesnik
Sep 1, 1969·The American Journal of Physiology·A MallianiA Zanchetti
Dec 1, 1965·The American Journal of Physiology·G AscanioM J Oppenheimer
Feb 1, 1963·The American Journal of Cardiology·L COSTANTIN
Jul 1, 1964·Clinical Pharmacology and Therapeutics· VON EULERU

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Citations

Jan 1, 1989·Journal of the American College of Cardiology·W J WelchD L Eckberg
Jan 1, 1994·Journal of the American College of Cardiology·W J RemmeP W de Leeuw
Aug 1, 1996·The American Journal of Cardiology·S P SedlisE H Steinberg
Feb 25, 1998·Pacing and Clinical Electrophysiology : PACE·E GiannitsisU Stierle
Jun 20, 1998·Journal of Endocrinological Investigation·A Roth-IsigkeitP Schmucker
Nov 1, 1981·Archives internationales de physiologie et de biochimie·J KedemJ Sonn
Sep 15, 1990·The American Journal of Cardiology·S P SedisH M Altszuler
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G H Rao, J G White
Oct 1, 1993·The American Journal of Cardiology·D LapennaF Cuccurullo
Jun 29, 2000·Scandinavian Cardiovascular Journal : SCJ·K Ylitalo, K Peuhkurinen
Oct 1, 1983·Journal of the American College of Cardiology·R J Weiss, C B Smith
Sep 1, 1983·The American Journal of Cardiology·E Thaulow
Feb 26, 2000·Anesthesiology·D A MacGregorP E Scuderi
Dec 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Tadanobu IrieMarmar Vaseghi
Jul 22, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·J KesslerS Albrechtsen
Jul 1, 1982·The American Journal of Physiology·J B HalterK L Gould
Nov 1, 1983·Circulation Research·P A Blombery, B G Heinzow

❮ Previous
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