Catecholamines increase monocyte TNF receptors and inhibit TNF through beta 2-adrenoreceptor activation

The American Journal of Physiology
X GuiraoS F Lowry

Abstract

Postinjury deficits in monocyte tumor necrosis factor receptors (moTNFR) activity may alter beneficial functions during an inflammatory response. Several counter-regulatory hormones elicited during inflammation may modulate tumor necrosis factor (TNF) activity, but little is known about their influence on moTNFR. Also, catecholamines inhibit TNF production, but the adrenoreceptor mechanism of this effect has not been fully clarified. To determine the effect of catecholamines and corticosteroids on moTNFR, whole blood was coincubated for up to 8 (moTNFR) or 24 h (cytokines) in the presence of lipopolysaccharide (100 ng/ml) and 1) epinephrine (Epi, 10(-6) M), dexamethasone (Dex, 10(-6) M) or both (EpiDex, 10(-6) M) to assess the expression of total moTNFR, moTNFR-I, and moTNFR-II. 2) Epi and norepinephrine (EpiNE, 10(-6) M) and the alpha 1 + 2-, beta 1 + 2-, beta 1-, or beta 2-adrenergic antagonists were used to assess the role of such adrenoreceptors on total moTNFR and TNF production, and N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP) alone or in combination with the phosphodiesterase inhibitor Ro-20-1724/000, to study the cAMP-dependent pathway on total moTNFR. We found that Epi upregulated total moTNFR and mo...Continue Reading

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Citations

Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E MillerR H Straub
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S YangP Wang
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A W SielenkämperW J Sibbald
Sep 8, 2001·American Journal of Physiology. Cell Physiology·R L StarkieM A Febbraio
Apr 5, 2011·Biomarker Insights·Abdolreza Sotoodeh JahromiAbdolhossein Madani
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ju-Feng WangJames P Morgan

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