Catecholamines inhibit leukotriene formation and decrease leukotriene/prostaglandin ratio

Biochemical Pharmacology
J ParantainenH Vapaatalo

Abstract

Adrenaline, noradrenaline, isoprenaline, and to a lesser extent dopamine inhibit the release of leukotriene (LT) B2 from calcium ionophore-stimulated human polymorphonuclear leukocytes, while the release of prostaglandin (PG) E2 is proportionally elevated. The inactivity of salbutamol, a noncatechol adrenergic beta 2-receptor agonist, and the inability of propranolol to antagonize the effects of adrenaline, suggest the mediation through beta-receptor independent mechanisms. Neither are alpha-1-receptors involved, as prazosin, a specific antagonist, fails to inhibit the reaction. As the principles for biochemical regulation of LT- and PG-production are met by catecholamines in several tissues, the mechanism is considered to be of general physiological importance. Catecholamines may function as coenzymes/antioxidants which, by altering the redox state of the enzyme iron or heme, decrease the LT/PG ratio thus protecting the organism against tissue anaphylaxis and other LT-related pathophysiology.

References

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Citations

Dec 31, 1997·Biochemical Pharmacology·J AlankoJ Parantainen
Oct 1, 1993·American Journal of Obstetrics and Gynecology·S A Laifer, P N Rauk
Jan 1, 1992·Scandinavian Journal of Gastroenterology·P A Aho, I B Lindén
Jan 16, 1999·Journal of Cardiovascular Pharmacology·T KerttulaS Kaukinen
Jul 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T KerttulaJ Alanko

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.