DOI: 10.1101/479519Nov 26, 2018Paper

Categorical encoding of decision variables in orbitofrontal cortex

BioRxiv : the Preprint Server for Biology
Arno OnkenCamillo Padoa-Schioppa


A fundamental and recurrent question in systems neuroscience is that of assessing what variables are encoded by a given population of neurons. Such assessments are often challenging because neurons in one brain area may encode multiple variables, and because neuronal representations might be categorical (different neurons encoding different variables) or mixed (individual neurons encoding a combination of variables). These issues are particularly pertinent to the representation of decision variables in the orbitofrontal cortex (OFC) – an area implicated in economic choices. Here we present a new algorithm to assess whether a neuronal representation is categorical or mixed, and to identify the encoded variables if the representation is indeed categorical. The algorithm is based on two clustering procedures, one variable-independent and the other variable-based. The two partitions are then compared through adjusted mutual information. The present algorithm overcomes limitations of previous approaches and is widely applicable. We tested the algorithm on synthetic data and then used it to examine neuronal data recorded in the primate OFC during economic decisions. Confirming previous assessments, we found the neuronal representatio...Continue Reading

Related Concepts

Cerebral Cortex
Population Group
Orbitofrontal Cortex

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