Categorization of major and minor complications in the treatment of patients with resectable rectal cancer using short-term pre-operative radiotherapy and total mesorectal excision: a Delphi round

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
R BakxJ J B van Lanschot

Abstract

To properly balance the benefit (reduction of local recurrence) of short-term pre-operative radiotherapy for resectable rectal cancer against its harm (complications), a consensus concerning the severity of complications is required. The aim of this study was to reach consensus regarding major and minor complications after short-term radiotherapy followed by total mesorectal excision in the treatment of rectal carcinoma, using the Delphi technique. A Delphi round was performed in cooperation with 21 colo-rectal surgeons from the Netherlands, United Kingdom and Sweden. The key-question was: 'Which of the predefined complications, caused or substantially aggravated by radiotherapy, are so important (major) that they might lead to the decision to abandon short-term pre-operative radiotherapy (5 x 5Gy) when treating patients with resectable rectal cancer (T1-3N0-2M0)?' After three rounds, consensus was reached for 37 (68%) of 54 complications of which 13 were considered major and 24 considered minor. The following complications were considered to be major: mortality, anastomotic leakage managed by relaparotomy, anastomotic leakage resulting in persisting fistula, postoperative haemorrhage managed by relaparotomy, intra-abdominal ab...Continue Reading

References

Nov 1, 1987·Journal of Advanced Nursing·C M Goodman
Oct 1, 1984·ANS. Advances in Nursing Science·M R Couper
Oct 1, 1994·Annals of Surgery·H J WaneboD E Wrobleski
Mar 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J FrykholmB Glimelius
Aug 5, 1995·BMJ : British Medical Journal·J Jones, D Hunter
Mar 1, 1996·The British Journal of Surgery·P M Sagar, J H Pemberton
Feb 27, 2001·International Journal of Nursing Studies·S KeeneyH P McKenna
Jun 22, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J Camilleri-Brennan, R J Steele
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A M MarijnenUNKNOWN Cooperative Investigators of the Dutch Colorectal Cancer Group
Mar 21, 2002·The Lancet Oncology·Ilora G Finlay, Bertus van Dijk
Aug 7, 2002·Burns : Journal of the International Society for Burn Injuries·Simon CarleyKen Dunn
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nestor F EsnaolaJohn M Skibber
Nov 19, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A W BradburyF G R Fowkes
Nov 20, 2002·ANZ Journal of Surgery·Alan P Meagher, Robyn L Ward
Jan 7, 2003·Annals of Surgical Oncology·Thomas J MinerW Douglas Wong
Feb 13, 2003·Journal of Advanced Nursing·Catherine Powell
Feb 11, 2004·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Pamela E Windle
Mar 11, 2004·Journal of Advanced Nursing·Holly Powell Kennedy
Sep 1, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R BakxF A N Zoetmulder
May 19, 2005·International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association·Hugh Cross

❮ Previous
Next ❯

Citations

Jul 31, 2013·Archives of Orthopaedic and Trauma Surgery·M S H BeerekampJ C Goslings
Jul 22, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·B SzynglarewiczJ Kornafel
Aug 13, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A DoeksenJ J B van Lanschot
Oct 7, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J TiernanN Fearnhead
Nov 22, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A G K McNairUNKNOWN ORACLE Collaboration

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.