Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage

Oxidative Medicine and Cellular Longevity
Huda Mohammed Alkreathy, Aftab Ahmad

Abstract

Catharanthus roseus (C. roseus) and ursolic acid (UA) are ayurvedic medicines with multiple pharmacological activities including antidiabetic activity, but till date, no study is available on their combination. This study documented the antidiabetic efficacy of the combination of C. roseus and UA in rats. Rats were divided into six groups. All groups were given a single dose of Streptozotocin (STZ) at a dose of 50 mg/kg by intraperitoneal route for induction of diabetes, except the normal control group. Group 1 was treated as a normal control (NC) group and fed with saline water, Group 2 as a Diabetes Control group, Group 3 as a STZ+C. roseus ethanolic extract (CREE) group at 50 mg/kg p.o., Group 4 as a STZ+UA group orally at 50 mg/kg, Group 5 as a STZ+CREE (25 mg/kg p.o.)+UA (25 mg/kg p.o.) group, and Group 6 as a STZ+Glimepiride (0.1 mg/kg) group. Diabetes was confirmed after 72 hours by estimation of blood glucose level, and then treatment was given for the next 28 days. During the course of treatment, plasma insulin and blood glucose were measured regularly at the interval of 7 days. At the end of the protocol, blood was collected and animals were sacrificed. The glucose level, insulin level, liver glycogen storage level, a...Continue Reading

References

Sep 13, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Kurup, R R Bhonde
Mar 23, 2004·Current Medicinal Chemistry·Robert van Der HeijdenRobert Verpoorte
Jan 15, 2008·European Journal of Medicinal Chemistry·Simone C B GnoattoSafa Moslemi
Feb 4, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ramesh Babu KasettiChippada Appa Rao
Aug 17, 2010·Chemico-biological Interactions·J ElizaS Ignacimuthu
Jan 27, 2011·European Journal of Pharmacology·Atsuo TaharaMasayuki Shibasaki
Jun 9, 2011·Journal of Natural Products·Julius LiobikasJurga Bernatoniene
Jul 1, 2011·Journal of Biomedicine & Biotechnology·Xuemei WangXiulan Su
Mar 1, 2012·Sultan Qaboos University Medical Journal·Fatmah A MatoughJamaludin Mohamed
Sep 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aditya AryaMustafa Ali Mohd
Sep 11, 2014·Neural Regeneration Research·Biao LiuJiajun Chen
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Łukasz WoźniakKrystian Marszałek
Jun 14, 2016·Journal of Diabetes Research·Du-Bois AsanteJoseph Budu Dadzie
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rahul ChandranSajeesh Thankarajan
Jul 13, 2017·Oxidative Medicine and Cellular Longevity·Ilaria MarroccoIlaria Peluso
Mar 3, 2018·Diabetes Research and Clinical Practice·N H ChoB Malanda
Oct 23, 2018·Journal of Diabetes Research·Yanlin Wang-Fischer, Tina Garyantes
Dec 19, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Rosa VonaDonatella Pietraforte
Aug 14, 2019·EBioMedicine·Mitchell A Sullivan, Josephine M Forbes
Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
Nov 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chung-Ze WuJin-Shuen Chen

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Vuyolwethu KhwazaBlessing A Aderibigbe

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Methods Mentioned

BETA
amputation

Software Mentioned

SPSS ( Statistical Package for the Social Sciences )

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