Cathelicidin deficiency predisposes to eczema herpeticum.

The Journal of Allergy and Clinical Immunology
Michael D HowellDonald Y M Leung

Abstract

The cathelicidin family of antimicrobial peptides is an integral component of the innate immune response that exhibits activity against bacterial, fungal, and viral pathogens. Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV). This study investigated the potential role of cathelicidins in host susceptibility to HSV infection. Glycoprotein D was measured by means of real-time RT-PCR as a marker of HSV replication in skin biopsy specimens and human keratinocyte cultures. Cathelicidin expression was evaluated in skin biopsy specimens from patients with AD (n = 10) without a history of HSV skin infection and from patients with ADEH (n = 10). The cathelicidin peptide LL-37 (human cathelicidin) exhibited activity against HSV in an antiviral assay, with significant killing (P < .001) within the physiologic range. The importance of cathelicidins in antiviral skin host defense was confirmed by the observation of higher levels of HSV-2 replication in cathelicidin-deficient (Cnlp-/-) mouse skin (2.6 +/- 0.5 pg HSV/pg GAPDH, P < .05) compared with that seen in skin from their wild-type counterparts (0.9 +/- 0.3). Skin from patients with AD...Continue Reading

References

Mar 14, 1987·British Medical Journal·I R SandersonJ I Harper
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·J Lagacé-SimardM A Wainberg
Aug 1, 1994·The Journal of Clinical Investigation·Q HamidD Y Leung
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·L B Bacharier, R S Geha
May 5, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B YasinE A Wagar
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Apr 12, 2003·Journal of Clinical Microbiology·Manfred WeidmannFrank T Hufert
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Andreas WollenbergJürgen Haas
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Michael D HowellDonald Y M Leung

❮ Previous
Next ❯

Citations

May 17, 2011·Cellular and Molecular Life Sciences : CMLS·Jamie J Bernard, Richard L Gallo
Jun 6, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H C RerinckA Wollenberg
Sep 25, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J SchmittM Meurer
Oct 23, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A WollenbergE D Renner
Nov 23, 2010·Cell and Tissue Research·Tova DybvigHeather L Wilson
Aug 11, 2006·Current Allergy and Asthma Reports·Peck Y Ong, Donald Y M Leung
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Andreas Wollenberg, Elisabeth Klein
Dec 25, 2010·Clinical Reviews in Allergy & Immunology·Andreas WollenbergJürgen Schauber
Feb 27, 2013·Antiviral Research·Donald Y M Leung
Jul 16, 2008·Expert Reviews in Molecular Medicine·Caroline BussmannNatalija Novak
Feb 1, 2011·Cellular & Molecular Immunology·Amy D ProalTrevor G Marshall
Feb 7, 2013·Pediatric Research·Shauna SchroederGlenn T Furuta
May 11, 2012·The New England Journal of Medicine·Bonnie T MackoolRosalynn M Nazarian
Apr 4, 2008·The New England Journal of Medicine·Thomas Bieber
Jan 26, 2011·Pediatric Dermatology·Stephanie Frisch, Elaine C Siegfried
Mar 10, 2011·Pediatric Dermatology·Hanan A SalemMamdouh Abd El Gawad
Sep 22, 2012·Pediatric Dermatology·Paul L AronsonSamir S Shah
Aug 26, 2009·Infection and Immunity·Bruno Rivas-SantiagoJ Antonio Enciso-Moreno
Jun 5, 2007·Pediatrics in Review·Tamar StrickerFelix H Sennhauser
Mar 19, 2014·Current Allergy and Asthma Reports·Rachana Agrawal, Judith A Woodfolk
Feb 4, 2014·Drug Discovery Today. Disease Mechanisms·Keith D Roby, Anna Di Nardo
Oct 5, 2007·Journal of Pharmaceutical Sciences·Sarika NamjoshiHeather A E Benson
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·I-Hsin KuoLisa A Beck
Jul 31, 2012·The Journal of Allergy and Clinical Immunology·Lianghua BinDonald Y M Leung
Aug 23, 2011·The American Journal of Medicine·Maryrose LaguioPeter Mariuz
Jun 18, 2011·Clinics in Dermatology·Christine BangertGeorg Stingl
Oct 30, 2015·Pediatrics and Neonatology·I-Jen WangKuo-Wei Yeh
May 3, 2011·Analytical Biochemistry·Mónica Calderón-SantiagoMaría Dolores Luque de Castro
May 5, 2011·Peptides·Jack Ho WongDavid Chi Cheong Wan
Mar 23, 2011·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
Jul 31, 2010·Immunology and Allergy Clinics of North America·Daniel A Searing, Donald Y M Leung
Jul 31, 2010·Immunology and Allergy Clinics of North America·Peck Y Ong, Donald Y M Leung
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Luz S FonacierDonald Y M Leung
Aug 22, 2009·Clinics in Dermatology·Lijuan Zhang, Timothy J Falla
Sep 8, 2009·The Journal of Allergy and Clinical Immunology·Pei-Song GaoDonald Y M Leung
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Lisa A BeckDonald Y M Leung
Oct 20, 2010·Pediatric Annals·Melinda Jen, Mary Wu Chang
Feb 17, 2009·Trends in Immunology·Yuping Lai, Richard L Gallo
Dec 17, 2008·The Journal of Investigative Dermatology·Anna De BenedettoLisa A Beck

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

The Journal of Allergy and Clinical Immunology
Michael D HowellDonald Y M Leung
The Journal of Allergy and Clinical Immunology
Lisa A BeckDonald Y M Leung
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Michael D HowellDonald Y M Leung
© 2022 Meta ULC. All rights reserved