Cathelicidin LL-37. A central factor in the pathogenesis of inflammatory dermatoses?

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
Jürgen SchauberR A Rupec

Abstract

Keratinocytes produce and secrete antimicrobial peptides which function as endogenous antibiotics and as signaling molecules within the cutaneous innate immune system. Recent studies demonstrate that the antimicrobial peptide cathelicidin LL-37 plays an important role in the pathogenesis of atopic eczema, rosacea and psoriasis. Whereas skin in atopic eczema shows decreased cathelicidin expression which leads to increased susceptibility to superinfection in those patients, overabundant expression of cathelicidin peptide fragments causes inflammation in rosacea. Finally, in psoriasis cathelicidin peptide binds to self DNA which triggers an autoimmune response. These studies demonstrate the role of cathelicidin as a central factor in the pathogenesis of cutaneous inflammation. Therapies targeting cathelicidin expression and function could lead to new treatments for these diseases.

References

Jul 10, 2001·The Journal of Investigative Dermatology·Robert A DorschnerRichard L Gallo
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Jun 5, 2003·The Journal of Clinical Investigation·Rembert KoczullaRobert Bals
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ichiro NomuraDonald Y M Leung
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marissa H BraffRichard L Gallo
Oct 3, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenshi YamasakiRichard L Gallo
Feb 10, 2007·The Journal of Clinical Investigation·Jürgen SchauberRichard L Gallo
Aug 7, 2007·Nature Medicine·Kenshi YamasakiRichard L Gallo

Citations

Sep 12, 2012·Skin Pharmacology and Physiology·H C KortingM Schäfer-Korting
Feb 18, 2012·The Journal of Investigative Dermatology·Kimberly N KanadaRichard L Gallo

Related Concepts

Metazoa
Dermatitis
Signal Transduction
Cathelicidins

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