Cathelicidin Mediates a Protective Role of Vitamin D in Ulcerative Colitis and Human Colonic Epithelial Cells

Inflammatory Bowel Diseases
John GubatanAlan C Moss


Vitamin D plays a protective role in ulcerative colitis (UC) patients through unclear mechanisms. Cathelicidin is an antimicrobial peptide induced by 1,25(OH)D2. Our goal was to evaluate the link between cathelicidin and vitamin D-associated clinical outcomes in UC patients, explore vitamin D induction of cathelicidin in human colon cells, and evaluate the effects of intrarectal human cathelicidin on a murine model of colitis. Serum and colonic cathelicidin levels were measured in UC patients and correlated with clinical and histologic outcomes. Human colon cells were treated with 1,25(OH)2D and production of cathelicidin and cytokines were quantified. Antimicrobial activity against Escherichia coli from cell culture supernatants was measured. Mice were treated with intrarectal cathelicidin, and its effects on DSS colitis and intestinal microbiota were evaluated. In UC patients, serum 25(OH)D positively correlated with serum and colonic cathelicidin. Higher serum cathelicidin is associated with decreased risk of histologic inflammation and clinical relapse but not independent of 25(OH)D or baseline inflammation. The 1,25(OH)2D treatment of colon cells induced cathelicidin and IL-10, repressed TNF-α, and suppressed Escherichia c...Continue Reading


Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BalsJ M Wilson
Jun 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adrian F GombartH Phillip Koeffler
May 17, 2006·European Journal of Gastroenterology & Hepatology·Jürgen SchauberEduard F Stange
Feb 10, 2007·The Journal of Clinical Investigation·Jürgen SchauberR L Gallo
Apr 26, 2007·Gut·Sabine NudingEduard F Stange
May 1, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sunghan YimGill Diamond
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Juan KongYan Chun Li
Jul 19, 2011·Gastroenterology·Hon Wai KoonCharalabos Pothoulakis
Feb 15, 2012·Journal of Visualized Experiments : JoVE·Janice J KimWaliul I Khan
Apr 18, 2012·Journal of Gastroenterology and Hepatology·C C M WongChi Hin Cho
Aug 16, 2013·The Journal of Clinical Investigation·Weicheng LiuYan Chun Li
Aug 24, 2013·The Journal of Nutrition·Jot Hui OoiMargherita T Cantorna
Mar 3, 2015·Cellular and Molecular Gastroenterology and Hepatology·Jun Hwan YooHon Wai Koon
Mar 10, 2016·The American Journal of Gastroenterology·Toufic A KabbaniDavid G Binion
Jun 9, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John GubatanAlan C Moss
Aug 5, 2016·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Amrollah SharifiSaharnaz Nedjat
Feb 15, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teizo YoshimuraJi Ming Wang
May 16, 2018·Current Opinion in Gastroenterology·John Gubatan, Alan C Moss
Feb 1, 2019·Clinical Microbiology Reviews·Hengameh Chloé Mirsepasi-LauridsenAndreas Munk Petersen
Mar 9, 2019·Molecular Therapy Oncolytics·Jiani WangHon Wai Koon
Oct 28, 2019·Frontline Gastroenterology·Ole Haagen NielsenLars Rejnmark


Jun 17, 2020·Expert Review of Gastroenterology & Hepatology·Anthony MyintBerkeley N Limketkai
May 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Patricia Mae GarciaMee Young Hong
Jan 6, 2021·International Journal of Molecular Sciences·Carolina BattistiniJun Sun

Related Concepts

25-Hydroxyvitamin D 2
Cell Culture Techniques
Ulcerative Colitis
Colon Structure (Body Structure)
2D Echocardiography
Epithelial Cells
Escherichia coli
Objective (Goal)

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.