Cathepsin B: A sellsword of cancer progression

Cancer Letters
Olja MijanovićMaciej S Lesniak

Abstract

Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next - from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.

References

Jan 5, 2000·Genes & Development·J Rodriguez, Y Lazebnik
Jun 20, 2002·The Journal of Biological Chemistry·Jennifer E KoblinskiBonnie F Sloane
Jul 31, 2003·Biological Chemistry·Shiqing Yan, Bonnie F Sloane
Jan 5, 2006·Brain Pathology·Sajani S LakkaJasti S Rao
Sep 23, 2006·Nature Reviews. Cancer·Mona Mostafa Mohamed, Bonnie F Sloane
Nov 11, 2006·Circulation Research·Theodore W SmallJ Geoffrey Pickering
Nov 6, 2007·Cancer Letters·Stefano Fais
Jan 16, 2009·The FEBS Journal·Jerica Rozman PungercarBoris Turk
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·James L Cox
Jun 6, 2009·Neuroreport·José J RodríguezAlexei Verkhratsky
Jan 16, 2010·Apoptosis : an International Journal on Programmed Cell Death·Ann-Charlotte JohanssonKarin Ollinger
Sep 21, 2010·Biochimica Et Biophysica Acta·Giancarlo SolainiAlessandra Baracca
May 18, 2011·Journal of Proteome Research·Catherine A FormoloYetrib Hathout
Aug 16, 2011·Molecular Oncology·Sreelatha GopinathJasti S Rao
Aug 30, 2011·Molecular and Cellular Biochemistry·Qing-Yong ChenLi-Jun Wu
Jun 15, 2012·Archives of Gerontology and Geriatrics·Aleksandra Wyczałkowska-Tomasik, Leszek Pączek
Jun 30, 2012·Neoplasia : an International Journal for Oncology Research·Aleksandra GlogowskaThomas Klonisch
Jan 9, 2013·Expert Opinion on Therapeutic Targets·Christopher S Gondi, Jasti S Rao
May 31, 2013·Journal of Cell Science·Sonja Aits, Marja Jäättelä
Aug 15, 2013·Cancer Letters·Saravana R K MurthyY Peng Loh
Feb 25, 2014·Cell·Aurélie ErnstJonas Frisén
Jul 26, 2014·Trends in Cell Biology·Carmine Settembre, Andrea Ballabio
Jan 15, 2015·BioMed Research International·Marko NovinecBoris Turk

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Citations

Oct 2, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiaoli LanJia Xu
Mar 4, 2021·Journal of Medicinal Chemistry·Rao SongTao Yang
Mar 31, 2021·Cancer Metastasis Reviews·Victor Delprat, Carine Michiels
Jun 1, 2021·Cancer Biomarkers : Section a of Disease Markers·Xiang MaLi Yang
Jun 5, 2021·Advanced Drug Delivery Reviews·Yiyuan KangLongquan Shao
Jun 29, 2021·Analytical Chemistry·Xiaoxia ChenZijuan Hai
Nov 28, 2021·Pharmaceutics·Mohammad DoroudianSeamas C Donnelly

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