PMID: 9166974Apr 1, 1997Paper

Cathepsin B-like activity as a serum tumour marker in ovarian carcinoma

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
M WarwasM Nowak

Abstract

Serum cathepsin B-like activity was determined in 75 patients with ovarian carcinomas and in control groups. Ovarian cancers were of FIGO stages I-IV. Control groups consisted of 15 healthy women, 20 patients with myomas of the uterus, and 17 with benign ovarian cysts. Preoperative results showed elevated cathepsin B-like activity in 100% of the patients with ovarian cancers in relation to healthy subjects and patients with myomas, and in 78% in relation to benign ovarian cysts. Cathepsin B activity increased progressively with the FIGO stage of the disease, but the differences among particular stages were not statistically significant. In serous tumours cathepsin activity was significantly higher only in comparison to endometrioid ones (p < 0.001). Antipapain capacity of cystatins in the sera was also determined. No significant correlation between cathepsin B-like, and antipapain activity of cystatins was found. Serum cathepsin B-like activity may be helpful in the preoperative differential diagnosis between ovarian carcinomas and benign ovarian or uterine tumours.

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Citations

Nov 17, 2009·Journal of Cancer Research and Clinical Oncology·Eva KolwijckFred C G J Sweep
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Izabela Berdowska
Feb 27, 2004·Gynecologic Oncology·Hiroshi NishikawaKaoru Suzumori
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E KoblinskiB F Sloane
Aug 24, 2010·Reproductive Biology and Endocrinology : RB&E·Suzie E AhnGwonhwa Song
Aug 30, 2013·International Journal of Circumpolar Health·Elena A GashenkoTatyana A Korolenko
Oct 26, 2011·Biochimica Et Biophysica Acta·Vito TurkDušan Turk
Jun 14, 2005·Mayo Clinic Proceedings·Peter J TebbenRajiv Kumar
Jan 4, 2012·Proteomics. Clinical Applications·Peter Findeisen, Michael Neumaier
May 21, 2010·European Journal of Clinical Investigation·Eva KolwijckFred C G J Sweep
Jul 9, 2004·Pathology, Research and Practice·Christoph RöckenAlbert Roessner
Mar 12, 2005·World Journal of Gastroenterology : WJG·Elzbieta SkrzydlewskaStanislaw Sulkowski
Sep 6, 2019·Materials·Daniel EhrsamHenriette E Meyer Zu Schwabedissen

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