Cathepsin-D, adiponectin, TNF-α, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: a multicentric study

The Foot
Jamal AhmadSubhash K Wangnoo

Abstract

Diabetic foot, characterized by a pronounced inflammatory reaction, decreased collagen content and biosynthesis and accelerated degradation are crucial in wound healing. Cathepsin D, an aspartic endopeptidases implicated in cell growth, apoptosis, and its inhibitor has been reported to reverse the inhibition of collagen biosynthesis in wounded rat skin with diabetes. To date, the increased proteolytic activity of Cathepsin D in diabetic foot has not been evaluated and the pathogenic significance of the inflammation has received little attention. Of the patients [with ulcer (n=211) and without ulcer (n=208)], 89.73% had type 2 diabetes. Subjects with diabetic foot ulcer showed higher median plasma level of Cathepsin D [556.3 (312.6-587.3) RFC/ml vs 306.3 (92.6-337.3) RFC/ml], TNF-α [96.6 (79.9-121.5) ng/ml vs 8.4 (7.1-9.20) ng/ml], IL-6 [32.2 (8.52-48.4) ng/ml vs 4.9 (4.5-5.6) ng/ml], hsCRP [12.6 (11.2-14.1) mg/ml vs 3.90 (3.50-4.60) mg/ml] and lower median plasma levels of adiponectin [8.50 (7.10-9.5) ng/ml vs 13.3 (12.1-14.2) ng/ml]. A positive correlation was found between grades of ulcer, BMI, A1c and retinopathy for Cathepsin D, for adiponectin, between grades of ulcer, BMI, retinopathy, nephropathy & smoking, for IL-6, bet...Continue Reading

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Citations

Feb 19, 2013·Journal of Molecular Endocrinology·Li LingLi Yan
Sep 29, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mari KishibeKatherine A Radek
May 20, 2017·Current Diabetes Reviews·Zenith KhashimKathiravan Krishnan
Aug 21, 2019·Upsala Journal of Medical Sciences·Matthijs A VeldersPär Hedberg
Jan 1, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Finny MonickarajArup Das
Jan 11, 2020·Internal and Emergency Medicine·Federico BiscettiRaffaele Landolfi
Oct 23, 2020·International Angiology : a Journal of the International Union of Angiology·Marta Spychalska-ZwolińskaJacek Budzyński
Jan 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoqin LeiJianwei Dou

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