Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis

International Journal of Cancer. Journal International Du Cancer
M MauriziS Mancuso

Abstract

Sixty-three patients with primary laryngeal squamous-cell carcinoma were followed up for a median of 33 months after surgery. Cathepsin D (Cath D) concentration was assayed using a solid phase 2-site immunoradiometric assay in which the first monoclonal antibody (MAb) was coated on the ELISA solid phase and the second one, MIG8 radiolabeled with 1125-EGF, was used as the tracer. The median value of Cath D (13.8 pM/mg protein) was chosen as cut-off. Cath D > or = median value was closely related to neck lymph node involvement at presentation and to a short metastasis-free survival (MFS) and actual overall survival (OS). The 5-year MFS was 71% for patients with Cath D < median value tumors as compared with 0% for patients with Cath D > or = median value tumors. Lymph node status at presentation was not related to a short MFS and OS. Cox's univariate regression analysis using Cath D as a continuous variable showed that Cath D levels are correlated with neck lymph node metastasis. On multivariate analysis, Cath D status proved to be an independent factor for predicting a short MFS. Cath D assay may prove to be particularly useful in identifying laryngeal cancer patients who, with or without neck lymph node involvement at presentati...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·M MauriziG Cadoni
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P BrouilletH Rochefort
Feb 1, 1990·The New England Journal of Medicine·A K TandonW L McGuire
Jun 1, 1982·Clinical Otolaryngology and Allied Sciences·G B SnowA A Hart
Jan 1, 1993·The Laryngoscope·J C Irish, A Bernstein

❮ Previous
Next ❯

Citations

Dec 3, 1999·The British Journal of Dermatology·T HorikoshiM M Brysk
Jul 14, 2007·Urologia Internationalis·Axel S MerseburgerRainer Kuefer
Apr 14, 2000·Clinical Otolaryngology and Allied Sciences·J GreenmanN D Stafford
Aug 26, 1998·The Laryngoscope·M M BryskI Arany
May 29, 2007·European Journal of Cell Biology·Aruna VashishtaVaclav Vetvicka
Aug 24, 2005·European Urology·Axel S MerseburgerMarkus A Kuczyk
Jun 13, 2000·Journal of Chemical Information and Computer Sciences·S SeiwerthD Danić
Mar 11, 2008·Current Opinion in Otolaryngology & Head and Neck Surgery·Giovanni AlmadoriGaetano Paludetti
Jul 27, 2011·Journal of Cancer Research and Clinical Oncology·Mustafa PaksoyCakır Caglar
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·G AlmadoriF Ottaviani
Nov 12, 1998·Biochimie·T HorikoshiM M Brysk
Jan 13, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BaekelandtG B Kristensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The New England Journal of Medicine
A K TandonW L McGuire
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R ZeillingerE Kubista
© 2021 Meta ULC. All rights reserved