PMID: 2503442Apr 1, 1989Paper

Cathepsin G degrades denatured collagen

Inflammation
C Capodici, R A Berg

Abstract

Neutrophils are known to contain several metalloproteinases that can damage collagen, a major structural component of the extracellular matrix. Here a neutrophil serine proteinase secreted from activated neutrophils was shown to cleave denatured collagen (gelatin). This serine proteinase was not inhibited by synthetic inhibitors of elastase (elastatinal or Me-O-suc-Ala-Pro-Val-CH2Cl). However, a synthetic inhibitor of cathepsin G (Z-Gly-Leu-Phe-CH2Cl) was able to inhibit the serine proteinase having gelatinolytic activity, indicating that cathepsin G, a major serine proteinase, from neutrophils is responsible for cleaving gelatin. Purified cathepsin G was also shown to degrade gelatin. In further experiments, oxidized glutathione was able to enhance the gelatinolytic activity of cathepsin G. These results show that cathepsin G is capable of cleaving denatured collagen, and its activity is enhanced or stabilized in the presence of glutathione. The data support the concept that cathepsin G released from neutrophils could play a major role in degrading collagen during inflammation and may in part account for the degradation of extracellular matrix during inflammation.

References

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Citations

Jul 12, 2002·Microscopy Research and Technique·Wolf D Splettstoesser, Peter Schuff-Werner
Jun 1, 1989·Inflammation·C CapodiciR A Berg
Sep 1, 1991·Agents and Actions·C Capodici, R A Berg
Aug 1, 1994·International Journal of Immunopharmacology·M J Janusz, M Hare
Jun 23, 2011·The Journal of Biological Chemistry·Daniel C HoffmannSabine A Eming
Dec 4, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher J Kuckleburg, Peter J Newman
Feb 9, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Charles W McMonniesCaroline A Blackie
Nov 27, 2007·Free Radical Biology & Medicine·Yukihiro TsuchiyaHiroshi Hojo
Mar 1, 2006·European Journal of Immunology·Susan E RobertsonIain B McInnes
Nov 7, 2018·Journal of Wound Care·Hannah TrøstrupMagnus S Ågren
Jan 25, 2018·Journal of Cellular and Molecular Medicine·Dimitry A ChistiakovAlexander N Orekhov
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars TauschOliver Werz
Apr 22, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Claudia M Arenas GómezKaren Echeverri
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Naimeh RafatianStewart C Whitman
Nov 30, 2019·Cellular Signalling·A Sainio, H Järveläinen

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