Cathepsins and their involvement in immune responses

Swiss Medical Weekly
Sébastien Conus, Hans-Uwe Simon

Abstract

The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases.

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