Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors.

Journal of Cancer Research and Clinical Oncology
Eva KolwijckFred C G J Sweep

Abstract

In cancer, an extracellular and membrane bound localization of cathepsins contribute to the invasion of tumor cells at the basement membrane. This is the first study that explored levels of cathepsins B (CatB), L (CatL) and their inhibitor cystatin C (CysC) in the cystic fluid (CF) of ovarian tumors (n = 110). CF contained considerable amounts of CatB, CatL and CysC. Remarkable differences in CatB and CatL and CysC CF levels were found between different histopathological tumor subtypes. Levels of CatB and CysC were significantly higher in CF of malignant serous tumors compared to those found in benign serous tumors (p = 0.010 and p = 0.001 respectively), whereas levels of CatL were significantly higher in CF of malignant mucinous tumors compared to those found in benign mucinous tumors (p = 0.035). CatB and CysC showed a strong correlation in the group of patients with malignant serous tumors (p < 0.001; R = 0.921) suggesting that the increase in CatB might be balanced by a corresponding increase in CysC. Further studies are warranted to investigate cathepsins as possible prognostic biomarkers for the aggressiveness of ovarian cancer.

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Citations

Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Wei ZhangLi Li
Aug 24, 2010·Reproductive Biology and Endocrinology : RB&E·Suzie E AhnGwonhwa Song
Aug 30, 2013·International Journal of Circumpolar Health·Elena A GashenkoTatyana A Korolenko
May 21, 2010·European Journal of Clinical Investigation·Eva KolwijckFred C G J Sweep
Sep 21, 2010·Gynecologic Oncology·Daniel W CramerRoss S Berkowitz
Sep 30, 2020·Expert Review of Anticancer Therapy·Gaetano Leto, Maria Vittoria Sepporta
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Gang LiRaymond E Moellering

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