Catheter ablation of atrial fibrillation with heart failure: An updated meta-analysis of randomized trials

International Journal of Cardiology
Babikir KheiriDeepak L Bhatt

Abstract

Atrial fibrillation (AF) and heart failure (HF) often coexist. We conducted this meta-analysis to assess the efficacy and safety of catheter ablation in this population. Electronic databases were searched for all randomized clinical trials (RCTs) that evaluated catheter ablation in patients with left ventricular systolic dysfunction (LVSD). We calculated the weighted mean differences (MDs) and risk ratios (RRs) using a random-effects model. We included 7 RCTs with 851 patients (mean follow-up was 18 months). Catheter ablation in patients with LVSD was associated with significantly lower HF hospitalization rates (RR 0.57; 95% CI: 0.45-0.72; P < 0.01), reduced all-cause mortality (RR 0.52; 95% CI: 0.35-0.76; P < 0.01), improved left ventricular ejection fraction (MD 7.40; 95% CI: 3.37-11.43; P < 0.01), increased 6-minute walk test (MD 26.96; 95% CI: 6.39-47.54; P = 0.01), and improved peak oxygen consumption (VO2) (MD 3.17; 95% CI: 1.05-5.28; P < 0.01), without significant increased risks of serious adverse events (RR 1.05; 95% CI: 0.96-1.16; P = 0.30) compared with medical treatment. In this meta-analysis of RCTs, catheter ablation was associated with significant improvements in the clinical, structural, and functional capacity ...Continue Reading

Citations

Jun 4, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Helmut Pürerfellner
Mar 16, 2019·JAMA : the Journal of the American Medical Association·Christine M Albert, Deepak L Bhatt
Apr 12, 2019·Heart Failure Reviews·Michele CorrealeNatale Daniele Brunetti
Feb 23, 2019·Current Cardiology Reports·Alex Baher, Nassir F Marrouche

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