Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design

American Heart Journal
Douglas L PackerCABANA Investigators

Abstract

The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA,NCT00911508)(1) trial is testing the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of eliminating atrial fibrillation (AF) is superior to current state-of-the-art pharmacologic therapy. This international 140-center clinical trial was designed to randomize 2200 patients to a strategy of catheter ablation versus state-of-the-art rate or rhythm control drug therapy. Inclusion criteria include: 1) age> 65, or ≤65 with≥ 1 risk factor for stroke, 2) documented AF warranting treatment, and 3) eligibility for both catheter ablation and≥ 2 anti-arrhythmic or≥ 2 rate control drugs. Patients were followed every 3 to 6 months (median 4 years) and underwent repeat trans-telephonic monitoring, Holter monitoring, and CT/MR in a subgroup of patient studies to assess the impact of treatment on AF recurrence and atrial structure. With 1100 patients in each treatment arm, CABANA is projected to have 90% power for detecting a 30% relative reduction in the primary composite endpoint of total mortality, disabling stroke, serious bleeding, or cardiac arrest. Secondary endpoints include total mortality; mort...Continue Reading

Associated Clinical Trials

Jun 2, 2009·Douglas L. Packer, MDDouglas L. Packer, MD

Citations

Jan 18, 2019·Clinical Cardiology·Beatriz Tose Costa PaivaSonia Busch
Mar 16, 2019·European Heart Journal·Peter A NoseworthyXiaoxi Yao
Mar 26, 2019·Pacing and Clinical Electrophysiology : PACE·Ozcan OzekeDursun Aras
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Clinical Trials Mentioned

NCT00911508

Software Mentioned

EQOL CC
Medicomp
CABANA

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