PMID: 12767654May 28, 2003Paper

Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study

Journal of the American College of Cardiology
S FuchsS E Epstein

Abstract

We conducted a pilot study to evaluate the feasibility of transendocardial delivery of autologous bone marrow (ABM) strategy in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization. Transendocardial injection of ABM cells appears to enhance perfusion of ischemic porcine myocardium. Ten patients underwent transendocardial injection of freshly aspirated and filtered unfractionated ABM using left ventricular electromechanical guidance. Twelve injections of 0.2 ml each were successfully delivered into ischemic noninfarcted myocardium pre-identified by single-photon emission computed tomography perfusion imaging. Autologous bone marrow injection was successful in all patients and was associated with no serious adverse effects; in particular, there was no arrhythmia, evidence of infection, myocardial inflammation, or increased scar formation. Two patients were readmitted for recurrent chest pain. At three months, Canadian Cardiovascular Society angina score significantly improved (3.1 +/- 0.3 vs. 2.0 +/- 0.94, p = 0.001), as well as stress-induced ischemia occurring within the injected territories (2.1 +/- 0.8 vs. 1.6 +/- 0.8, p < 0.001). Treadmill exercise duration, available in...Continue Reading

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References

Mar 20, 2002·Circulation·Cindy L GrinesRobert L Engler
May 3, 2002·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Manuel D CerqueiraUNKNOWN American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging

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Citations

Oct 6, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Frank M BengelStefanie Dimmeler
Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·L BindslevJ Kastrup
Apr 28, 2005·European Radiology·M SaeedC Higgins
Oct 21, 2005·Basic Research in Cardiology·H C OttD A Taylor
Nov 26, 2005·Angiogenesis·Daniela Tirziu, Michael Simons
Jun 4, 2011·Cardiovascular Drugs and Therapy·Drew KuraitisErik J Suuronen
Nov 30, 2006·Heart Failure Reviews·Frank M Bengel
Aug 29, 2006·Heart Failure Reviews·E LeontiadisD V Cokkinos
Aug 2, 2007·Heart Failure Reviews·Marton VertesaljaiPeter Andreka
Jun 19, 2013·Journal of General Internal Medicine·Shannon B PuliaficoKevin H Silver
Jul 23, 2005·Current Heart Failure Reports·Patrick I McConnell, Robert E Michler
Nov 3, 2006·Current Treatment Options in Cardiovascular Medicine·Hüseyin InceChristoph A Nienaber
Jul 24, 2008·Current Treatment Options in Cardiovascular Medicine·Bruno K PodesserRonglih Liao
Jun 1, 2008·Journal of Cardiovascular Translational Research·Cindy M Martin
Jun 19, 2010·Journal of Cardiovascular Translational Research·Eric Fuh, Todd J Brinton
Dec 25, 2010·Journal of Cardiovascular Translational Research·Nabil DibAnn Campbell
Jul 30, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Frank M Bengel
Apr 25, 2007·American Heart Journal·E Marc JolicoeurUNKNOWN National Heart, Lung, and Blood Institute Cell Therapy Working Group Members
May 28, 2005·The Annals of Thoracic Surgery·Shafie FazelTerrence M Yau
Apr 9, 2013·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Charles R HattAmish N Raval
Sep 21, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Claudio T MesquitaHans Fernando R Dohmann
Feb 27, 2004·Cardiovascular Radiation Medicine·Ron Waksman, Richard Baffour
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Noel M CapliceJorge R Alegria
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Simón Méndez-FerrerBernardo Nadal-Ginard
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Pedro L SánchezFrancisco Fernández-Avilés
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Ana SánchezJavier García-Sancho
Feb 6, 2008·Nature Clinical Practice. Cardiovascular Medicine·Steve RamcharitarPatrick W Serruys
May 21, 2008·Nature Clinical Practice. Cardiovascular Medicine·L Christian Napp, Helmut Drexler
Apr 14, 2009·Antioxidants & Redox Signaling·Husnain Kh HaiderMuhammad Ashraf
Feb 11, 2009·Antioxidants & Redox Signaling·Mohammad N Jameel, Jianyi Zhang
May 23, 2012·Tissue Engineering. Part a·Ling QianPhilip Wong
Jul 8, 2009·Cardiovascular Research·Susan T Laing, David D McPherson
Jun 17, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jörg HonoldStefanie Dimmeler
Aug 19, 2008·Cardiology in Review·Anna AhnMichael Nelson
Apr 29, 2006·Artificial Organs·A Ruchan AkarUmit Ozyurda

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