Catheter-related candidemia caused by Candida lipolytica in a patient receiving allogeneic bone marrow transplantation.

Journal of Clinical Microbiology
D D'AntonioGiuseppe Carruba

Abstract

Candida lipolytica was recovered from the blood and the central venous catheter in a patient receiving allogeneic bone marrow transplantation. Two C. lipolytica strains from different geographical areas and the ATCC 9773 strain of C. lipolytica were used as controls. C. lipolytica was identified by standard methods. MICs indicated antifungal susceptibilities to amphotericin B, fluconazole, and itraconazole for all strains. In vitro testing and scanning electron microscopy showed that C. lipolytica was capable of producing large amounts of viscid slime material in glucose-containing solution, likely responsible for the ability of the yeast to adhere to catheter surfaces. Restriction fragment length polymorphisms revealed an identical profile for all clinical isolates, unrelated to those observed for the control strains. This finding suggested the absence of microevolutionary changes in the population of the infecting strain, despite the length of the sepsis and the potential selective pressure of amphotericin B, which had been administered to the patient for about 20 days. The genomic differences that emerged between the isolates and the control strains were indicative of a certain degree of genetic diversity between C. lipolyti...Continue Reading

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Citations

Jan 9, 2003·Journal of Clinical Microbiology·M A PfallerUNKNOWN International Fungal Surveillance Participant Group
Jan 31, 2007·Applied and Environmental Microbiology·N JainB C Fries
Sep 16, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D D'AntonioT Staniscia
Jun 13, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Wen-Cheng LiuSheng-Kang Chiu
Jul 4, 2012·The Journal of Infection·Chih-Cheng LaiPo-Ren Hsueh
Jul 29, 2009·Revista iberoamericana de micología·María Teresa BlancoFrancisca Guerrero
Mar 16, 2013·Critical Reviews in Microbiology·Marizeth GroenewaldMarkus Wyss
Jun 27, 2006·Scandinavian Journal of Infectious Diseases·Nurşen BeletUlker Doğru
Sep 24, 2004·Canadian Journal of Microbiology·Patrícia M PintoMiriam Tendler
Feb 6, 2009·Revista da Escola de Enfermagem da U S P·Rosimeire Barbosa Fonseca, Silvia Regina Secoli
Dec 24, 2018·World Journal of Microbiology & Biotechnology·Bartłomiej Zieniuk, Agata Fabiszewska
Jan 24, 2015·Mycopathologia·H TrabelsiA Ayadi

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