Catheter-related Malassezia furfur fungemia in immunocompromised patients

The American Journal of Medicine
G R BarberD Armstrong

Abstract

Malassezia furfur has usually been described as a cause of catheter-related sepsis in neonates receiving intravenous lipid emulsion. We report seven cases of catheter-related M. furfur fungemia that occurred in seven immunocompromised patients including four adults and three children who were not neonates. Only two of these patients were receiving concurrent intravenous lipid emulsion. All positive blood cultures were obtained from a central venous access device, one of which was a port device. Quantitative M. furfur colony counts ranged from 50 cfu/mL to greater than 1,000 cfu/mL. All seven patients were treated with amphotericin B. Blood drawn through the central lines of three patients yielded additional organisms. One central venous access device required removal due to persistently positive M. furfur blood cultures despite treatment with amphotericin B. We conclude that catheter-related M. furfur fungemia occurs in immunocompromised patients with central venous access devices whether or not they are receiving intravenous lipids. Prompt, aggressive treatment with amphotericin B (1 mg/kg/d) may spare patients removal of their central venous access device. Further studies are needed to determine the role of endogenous lipids ...Continue Reading

References

Feb 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W MyersS L Berk
Jun 1, 1968·The Biochemical Journal·P F Wilde, P S Stewart
Apr 1, 1969·The British Journal of Dermatology·S O Roberts
Aug 1, 1963·Journal of General Microbiology·M SHIFRINE, A G MARR

❮ Previous
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Citations

Mar 1, 1996·Nutrition·K A Adal, B M Farr
Oct 3, 1999·Critical Care Medicine·P Toltzis, J L Blumer
Jun 22, 2002·The Pediatric Infectious Disease Journal·Alexander T KesslerNeal Simon
Jan 11, 2012·Clinical Microbiology Reviews·Georgios GaitanisAristea Velegraki
Jan 10, 2002·Clinical Microbiology Reviews·H Ruth Ashbee, E Glyn V Evans
Jun 18, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·G DubarA Mignon
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L A MermelUNKNOWN Society for Healthcare Epidemiology of America
Feb 15, 2011·Infectious Disease Clinics of North America·George J Alangaden
Aug 30, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A H Groll, T J Walsh
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T J WalshE Anaissie
Mar 30, 2010·Clinics in Dermatology·Luis J Mendez-Tovar
Jun 6, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A H BlaesV A Morrison
Dec 24, 2009·Mycoses·Athanasios TragiannidisAndreas H Groll
Jun 1, 1996·Infectious Disease Clinics of North America·J N Greene
Jun 25, 2015·BioMed Research International·Laura Elena Carreto-BinaghiMaria Lucia Taylor
Nov 7, 2016·Infectious Disease Clinics of North America·Geehan Suleyman, George J Alangaden
May 31, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L A MermelUNKNOWN Society for Healthcare Epidemiology of America
Jan 1, 1996·Dermatologic Clinics·R R Assaf, M L Weil
Mar 15, 2018·Medical Mycology·Bart TheelenThomas L Dawson
Oct 18, 2000·Bone Marrow Transplantation·V A Morrison, D J Weisdorf
Nov 7, 2006·Journal of Cutaneous Pathology·Ranjitha VeerappanGeorge A Youngberg
Jan 25, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tetsuhiro YoshinoKatsuyuki Obara
Jul 16, 2019·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·I-Ting ChenKuang-Che Kuo
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Wafa RhimiClaudia Cafarchia
Sep 30, 2017·Frontiers in Microbiology·Sergio TrianaAdriana Celis
Aug 29, 2020·Open Forum Infectious Diseases·Alexander B Granok
Aug 15, 2020·Frontiers in Cellular and Infection Microbiology·Joleen P Z GohThomas L Dawson
Mar 31, 2011·Histopathology·Mohammed NaimMohammed K A Sherwani
Jun 2, 2000·Journal of Clinical Microbiology·M J CrespoF J Cabañes
Apr 16, 1999·Journal of Clinical Microbiology·M J CrespoF J Cabañes
Mar 4, 2000·Journal of Clinical Microbiology·M J CrespoF J Cabañes

❮ Previous
Next ❯

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