Cathodic-leading pulses are more effective than anodic-leading pulses in intracortical microstimulation of the auditory cortex

Journal of Neural Engineering
Mathias Benjamin Voigt, Andrej Kral

Abstract

Intracortical microstimulation (ICMS) is widely used in neuroscientific research. Earlier work from our lab showed the possibility to combine ICMS with neuronal recordings on the same shank of multi-electrode arrays and consequently inside the same cortical column in vivo. The standard stimulus pulse shape for ICMS is a symmetric, biphasic current pulse. Here, we investigated the role of the leading-phase polarity (cathodic- versus anodic-leading) of such single ICMS pulses on the activation of the cortical network. Local field potentials (LFPs) and multi-unit responses were recorded in the primary auditory cortex (A1) of adult guinea pigs (n  =  15) under ketamine/xylazine anesthesia using linear multi-electrode arrays. Physiological responses of A1 were recorded during acoustic stimulation and ICMS. For the ICMS, the leading-phase polarity, the stimulated electrode and the stimulation current where varied systematically on any one of the 16 electrodes while recording at the same time with the 15 remaining electrodes. Cathodic-leading ICMS consistently led to higher response amplitudes. In superficial cortical layers and for a given current amplitude, cathodic-leading and anodic-leading ICMS showed comparable activation patter...Continue Reading

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