Cathodic Voltage-controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model

Clinical Orthopaedics and Related Research
Scott R NodzoMark T Ehrensberger

Abstract

Cathodic voltage-controlled electrical stimulation (CVCES) of titanium implants, either alone or combined with a short course of vancomycin, has previously been shown to reduce the bone and implant bacterial burden in a rodent model of methicillin-resistant Staphylococcus aureus (MRSA) implant-associated infection (IAI). Clinically, the goal is to achieve complete eradication of the IAI; therefore, the rationale for the present study was to evaluate the antimicrobial effects of combining CVCES with prolonged antibiotic therapy with the goal of decreasing the colony-forming units (CFUs) to undetectable levels. (1) In an animal MRSA IAI model, does combining CVCES with prolonged vancomycin therapy decrease bacteria burden on the implant and surrounding bone to undetectable levels? (2) When used with prolonged vancomycin therapy, are two CVCES treatments more effective than one? (3) What are the longer term histologic effects (inflammation and granulation tissue) of CVCES on the surrounding tissue? Twenty adult male Long-Evans rats with surgically placed shoulder titanium implants were infected with a clinical strain of MRSA (NRS70). One week after infection, the rats were randomly divided into four groups of five: (1) VANCO: only...Continue Reading

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Citations

Jun 22, 2018·Current Reviews in Musculoskeletal Medicine·Mariam TahaAlberto V Carli
Jan 29, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emily K BrooksMark T Ehrensberger
Oct 16, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mohammed AshrafiArdeshir Bayat
Mar 17, 2020·Biomedical Engineering Letters·Mark T EhrensbergerEric P McDermott
Mar 17, 2020·Biomedical Engineering Letters·A L Overmann, J A Forsberg
May 13, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jua KimJeremy L Gilbert
Dec 28, 2017·ACS Infectious Diseases·Heidi WolfmeierRobert E W Hancock
Jan 20, 2021·ACS Biomaterials Science & Engineering·Hao WangDacheng Ren

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