Cation-chloride cotransporters: regulation, physiological significance, and role in pathogenesis of arterial hypertension

Biochemistry. Biokhimii︠a︡
S N OrlovS V Gusakova

Abstract

This review summarizes the data on the functioning of carriers providing electroneutral symport of sodium, potassium, and chloride (Na(+),K(+),2Cl(-) cotransport), potassium and chloride (K(+),Cl(-) cotransport), and sodium and chloride (K(+),Cl(-) cotransport) as well as molecular mechanisms of the regulation of these carriers and their physiological significance. We emphasized the involvement of chloride-coupled carriers in the regulation of cell volume and intracellular chloride concentration and novel data on the role of ubiquitous isoform of Na(+),K(+),2Cl(-) cotransporter NKCC1 in regulation of vascular smooth muscle contraction and activity of GABA(A) receptors. Finally, we analyzed the data on activation of NKCC1 in patients with essential hypertension and its role in the long-term maintenance of elevated systemic blood pressure and myogenic response in microcirculatory beds.

References

Nov 23, 1977·Pflügers Archiv : European journal of physiology·Y V PostnovA M Adler
Nov 1, 1990·Pharmacology & Toxicology·R TianF Andreasen
Oct 1, 1985·Physiological Reviews·Y V Postnov, S N Orlov
Sep 1, 1994·Experimental Physiology·M G MozhayevaJ I Gillespie
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·M BarthelmebsJ L Imbs
May 1, 1996·The American Journal of Physiology·S N OrlovP Hamet
Feb 11, 1998·Physiological Reviews·F LangD Häussinger
Oct 31, 1998·Journal of Hypertension·P HametJ Tremblay
Dec 23, 1998·British Journal of Clinical Pharmacology·F StankeG Bessard
Mar 10, 1999·The American Journal of Physiology·S N OrlovP Hamet
Apr 30, 1999·Physiological Reviews·M J Davis, M A Hill
Feb 9, 2000·American Journal of Physiology. Cell Physiology·N C AdragnaP K Lauf
Apr 25, 2000·Journal of Cardiovascular Pharmacology·F Stanke-LabesqueP Devillier
Oct 6, 2000·The Journal of Clinical Investigation·R S Williams, I J Benjamin
Feb 28, 2001·Progress in Biophysics and Molecular Biology·A R Chipperfield, A A Harper
Mar 10, 2001·Cell·R P LiftonD S Geller
Jul 10, 2001·American Journal of Physiology. Cell Physiology·B R GrubbR C Boucher
Aug 11, 2001·Science·F H WilsonR P Lifton
Nov 27, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander A. Mongin, Sergei N. Orlov
Mar 8, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·P HannaertR P Garay
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Gui SuDandan Sun
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Gui SuDandan Sun
Jul 30, 2002·The Journal of Biological Chemistry·Rachel B Darman, Biff Forbush
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Christian Lytle, Thomas McManus
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jamie W MeyerGary E Shull
Apr 2, 2003·Hypertension·Gengru JiangW Charles O'Neill

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Citations

Aug 26, 2016·Immunological Reviews·Guoshun Wang
Aug 5, 2017·Acta Pharmacologica Sinica·Ya-Juan ZhangYong-Yuan Guan
Aug 18, 2017·American Journal of Physiology. Cell Physiology·A P GarneauP Isenring
Oct 18, 2020·Cells·Nur Farah Meor Azlan, Jinwei Zhang

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