Cation metabolism during propofol sedation with and without EDTA in patients with impaired renal function

Intensive Care Medicine
J BarrD Teres

Abstract

To compare the effects of propofol with and without disodium edetate (EDTA) on cation metabolism in intensive care unit (ICU) patients with renal insufficiency who received propofol or propofol plus EDTA (propofol EDTA) for sedation and mechanical ventilation. Double-blind, randomised, multicentre study. Medical and surgical ICUs from 5 hospitals. Thirty-nine ICU patients with acute and chronic renal impairment expected to require at least 24 hours of continuous sedation and respiratory failure necessitating mechanical ventilation. Propofol or propofol EDTA administered for sedation by continuous intravenous infusion. The depth of sedation, as measured by the Modified Ramsay Sedation Scale, was similar in the 2 groups, when adjusted for dosing differences. The amount of propofol required to maintain adequate sedation was decreased in both groups compared to propofol requirements in ICU patients with normal renal function. EDTA levels were elevated at baseline in both groups. In the propofol EDTA group, the EDTA levels increased further by 20 % but decreased to below baseline EDTA levels at 48 hours after sedation. In the propofol group, EDTA levels decreased during sedation and remained below baseline levels at 48 hours after s...Continue Reading

Citations

Jun 3, 2014·Anesthesiology Clinics·M Stephen MeltonTong J Gan
Jun 19, 2013·Medicina intensiva·E Celis-RodríguezUNKNOWN Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva
Jul 4, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·F Sztark, F Lagneau
Sep 30, 2005·Anesthesiology·Max T Baker, Mohamed Naguib

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