Cationic anti-microbial peptides: from innate immunity study to drug development

La Revue de médecine interne
Emmanuel Andrès, J-L Dimarcq

Abstract

Host defense, cationic anti-microbial peptides are recognized as an important component of innate immune response in most multicellular organisms. They are cationic amphipathic peptides, comprising 20-50 amino acids. Several hundreds of peptides have been characterized. They have broad spectrum of activity against bacterial, fungal and viral pathogens. The mode of action is best known for cecropins and magainins, which act upon the cytoplasmic membrane of microorganisms, causing its disruption by a detergent like activity and pore formation. Several of these peptides or analogs (from magainin, protegrin, indolicidin and histatin) are in advanced clinical development, especially for localized infections. Several other molecules (rBPI, heliomicin and thanatine) are currently under development for various systemic infections. They may represent important drugs of the further anti-infectious therapeutic arsenal.

References

Feb 15, 1990·Biochemical Pharmacology·B A BerkowitzM A Zasloff
May 1, 1995·International Journal of Peptide and Protein Research·R J van AbelM E Selsted
Oct 25, 1996·Annals of the New York Academy of Sciences·R I Lehrer, T Ganz
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Apr 2, 1998·Current Opinion in Immunology·T Ganz, R I Lehrer
Aug 26, 1998·Scandinavian Journal of Immunology·H G Boman
Jan 8, 1999·Drugs·H M Lamb, L R Wiseman
Feb 27, 1999·Current Opinion in Immunology·R I Lehrer, T Ganz
May 20, 1999·Biopolymers·J L DimarcqJ Hoffmann
May 20, 1999·Biopolymers·F García-OlmedoP Rodríguez-Palenzuéla
May 21, 1999·Science·J A HoffmannR A Ezekowitz
May 29, 1999·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·D LouryJ C Fiddes
Jun 23, 1999·Molecular Medicine Today·T Ganz, R I Lehrer
Jul 30, 1999·Developmental and Comparative Immunology·P BuletD Hoffmann
Dec 10, 1999·Nature Biotechnology·H Breithaupt
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·K ThevissenW F Broekaert
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M G ScottR E Hancock
Nov 4, 2000·Expert Opinion on Investigational Drugs·R E Hancock
Nov 4, 2000·Expert Opinion on Investigational Drugs·L BellmT Ganz
Nov 23, 2000·Biochemistry·L OtvosM Blaszczyk-Thurin
Jan 6, 2001·Critical Reviews in Immunology·M G Scott, R E Hancock
Jan 30, 2002·FEMS Microbiology Letters·Robert E W Hancock, Annett Rozek
Mar 2, 2002·The Lancet Infectious Diseases·R E Hancock
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Dec 5, 2002·Current Drug Targets. Infectious Disorders·R E W Hancock, A Patrzykat
Dec 21, 2002·Journal of Clinical Periodontology·D W PaquetteR C Williams
Jun 7, 2003·The Journal of Infectious Diseases·Charles HetruJules A Hoffmann
Aug 22, 2003·Journal of Internal Medicine·H G Boman
Sep 19, 2003·International Journal of Antimicrobial Agents·Jean-Marie PagèsCharles Hetru
Oct 18, 2003·American Journal of Respiratory and Critical Care Medicine·Andrea GiacomettiGiorgio Scalise
Nov 7, 2003·Nature·Jules A Hoffmann
Mar 31, 2004·Journal of Internal Medicine·E Andrès, J L Dimarcq

❮ Previous
Next ❯

Citations

Oct 4, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Andrès
Feb 3, 2007·Natural Product Reports·Georgina EstradaGerardo Corzo
Jan 10, 2018·BMC Infectious Diseases·Ibrahim H BabikirIshag Adam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Related Papers

Journal of Internal Medicine
Emmanuel Andrès, J-L Dimarcq
International Journal of Antimicrobial Agents
K V R ReddyC Aranha
International Journal of Antimicrobial Agents
Emmanuel Andrès, Jean Luc Dimarcq
© 2021 Meta ULC. All rights reserved