Cationic cholesterol with a hydroxyethylamino head group promotes significantly liposome-mediated gene transfection

FEBS Letters
R OkayamaM Nakanishi

Abstract

A novel cationic cholesterol derivative with a hydroxyethylamino head group, cholesteryl-3beta-carboxyamidoethylene-N-hydroxyethylamine (II), has been synthesized and used for liposome-mediated gene transfection. The cationic liposomes containing the derivative (II) facilitated greatly pSV2CAT gene transfection into mouse NIH3T3 and L929 cells in the absence of serum. The transfection efficiency was much higher than those by the cationic liposomes containing cationic derivatives with a dialkylamino head group (I, III or IV). Further, the efficiency by the cationic liposomes with the derivative (II) was not so much decreased in the presence of serum. This suggested that a novel cationic cholesterol derivative (II) should be very promising in liposome-mediated gene transfection of plasmid and antisense DNA into target cells.

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Citations

Oct 9, 2013·Biochemical Pharmacology·Yoshikazu InohTadahide Furuno
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshikazu InohMamoru Nakanishi
Nov 20, 1998·Current Opinion in Biotechnology·D SchermanJ Crouzet
Apr 20, 2002·Bioorganic & Medicinal Chemistry Letters·Seiji HasegawaMamoru Nakanishi
Oct 29, 2002·Bioelectrochemistry·R I ZhdanovV V Vlassov
Jul 31, 2009·Chemical Communications : Chem Comm·Santanu Bhattacharya, Avinash Bajaj
Nov 18, 2000·Antisense & Nucleic Acid Drug Development·A CaoE Taillandier
Jun 2, 2007·Biological & Pharmaceutical Bulletin·Naohide HirashimaMamoru Nakanishi
Jan 5, 2007·Biological & Pharmaceutical Bulletin·Yoshinobu UenoMamoru Nakanishi
Jan 6, 2009·Biological & Pharmaceutical Bulletin·Yoshikazu InohMamoru Nakanishi
Jun 7, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mamoru Nakanishi
Nov 16, 2001·Biochemical and Biophysical Research Communications·Y InohM Nakanishi
Mar 12, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shoichiro NoguchiMamoru Nakanishi
Dec 25, 2007·International Journal of Pharmaceutics·Wuxiao DingYoshie Maitani
May 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiyuki HattoriYoshie Maitani
May 26, 2004·International Journal of Pharmaceutics·A PercotA Cao
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Jul 30, 2014·Frontiers in Pharmacology·Sonali Kapse-MistryMayur Yergeri
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Oct 6, 2006·Medicinal Research Reviews·Priya Prakash Karmali, Arabinda Chaudhuri
Dec 5, 2013·Pharmaceutics·Mamoru NakanishiTadahide Furuno
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naoto KatoNaohide Hirashima
Jul 8, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiyuki Hattori
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Nov 4, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Bappa Maiti, Santanu Bhattacharya

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