Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells

Analytical Chemistry
Pengbo ZhangShu Wang

Abstract

Bacteria quorum sensing (QS) has attracted significant interest for understanding cell-cell communication and regulating biological functions. In this work, we demonstrate that water-soluble cationic conjugated polymers (PFP-G2) can interact with bacteria to form aggregates through electrostatic interactions. With bacteria coated in the aggregate, PFP-G2 can induce the bacteria QS system and prolong the time duration of QS signal molecules (autoinducer-2 (AI-2)) production. The prolonged AI-2 can bind with specific protein and continuously regulate downstream gene expression. Consequently, the bacteria show a higher survival rate against antibiotics, resulting in decreased antimicrobial susceptibility. Also, AI-2 induced by PFP-G2 can stimulate 55.54 ± 12.03% more biofilm in E. coli. This method can be used to understand cell-cell communication and regulate biological functions, such as the production of signaling molecules, antibiotics, other microbial metabolites, and even virulence.

References

Mar 1, 1985·Microbiological Reviews·H Nikaido, M Vaara
Feb 23, 1999·Molecular Microbiology·M G Surette, B L Bassler
May 21, 1999·Science·J W CostertonE P Greenberg
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Aug 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brent S GaylordGuillermo C Bazan
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mauricio R Pinto, Kirk S Schanze
Feb 21, 2006·International Journal of Medical Microbiology : IJMM·Kok-Fai KongMichael Otto
Feb 25, 2006·Science·Andrew Camilli, Bonnie L Bassler
Sep 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ruth DanielsJan Michiels
Mar 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen P DiggleAshleigh S Griffin
Mar 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul WilliamsMiguel Cámara
Mar 28, 2007·Chemical Reviews·Samuel W ThomasTimothy M Swager
Jan 18, 2008·Accounts of Chemical Research·Hoang-A HoMario Leclerc
Sep 20, 2008·Organic & Biomolecular Chemistry·Paula OrtegaF Javier de la Mata
Nov 4, 2008·Current Opinion in Biotechnology·Sara Hooshangi, William E Bentley
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ilka B BischofsAdam P Arkin
Mar 17, 2010·Biomacromolecules·Elena V PiletskaSergey A Piletsky

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Citations

Apr 27, 2017·Angewandte Chemie·Nathan D KirchhoferGuillermo C Bazan
May 10, 2017·ACS Applied Materials & Interfaces·Pengbo ZhangShu Wang
Dec 17, 2016·Biosensors & Bioelectronics· KhoerunnisaSung Young Park
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huan-Huan RanFu-Gen Wu
Jan 28, 2020·Colloids and Surfaces. B, Biointerfaces·Pengbo ZhangShu Wang
Jan 10, 2020·ACS Chemical Biology·Alexander EddendenMark Nitz
Jan 26, 2022·Chemical Communications : Chem Comm·Yuhan KongHang Xing

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