Cationic liposomes modified with non-ionic surfactants as effective non-viral carrier for gene transfer

Colloids and Surfaces. B, Biointerfaces
Yongzhuo HuangWenquan Liang

Abstract

A defined change in formulation components affects the physical and chemical characteristics of cationic liposomes (CLs) carriers in many ways. Therefore, a great degree of control can be exercised over the structure by modifying the CLs with various materials, leading to new innovations for carrier improvement. In the present study, surface modifications of cationic liposomes with non-ionic surfactants--sorbitan monoesters serials (Span 85, 80, 40 and 20) were carried out for developing a new gene transfer carrier. Span modified cationic liposomes (Sp-CLs) were prepared by reverse phase evaporation method (RPV) and self-assemble complexes of antisense oligonucleotides/surfactant modifying cationic liposomes were prepared by auto-coacervation through electrostatic effect. Characterization of Sp-CLs and the self-assembled complex was performed by electron microscope, particle size, zeta potential, turbidity and agarose electrophoresis. Furthermore, in vitro cellular uptake experiment showed that Span plays a role in enhancing the cellular uptake of encapsulated oligonucleotides mediated by Sp-CLs by the endocytosis-dependent route. CLs modified with Span 40 significantly facilitated the cellular uptake by COS-7 cells and HeLa ce...Continue Reading

References

Aug 30, 1991·Biochemical and Biophysical Research Communications·X Gao, L Huang
Jun 11, 1999·International Journal of Pharmaceutics·J C BirchallS N Mills
Aug 6, 1999·Gene Therapy·J J WheelerP R Cullis
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·H KikuchiK Tanaka
Jun 14, 2000·Journal of Drug Targeting·P LemieuxA V Kabanov
Aug 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H TakeuchiY Kawashima
Feb 13, 2001·International Journal of Pharmaceutics·S P VyasV Sihorkar
Mar 17, 2001·Advanced Drug Delivery Reviews·J Kreuter
Apr 9, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·H HarashimaH Kiwada
Mar 9, 2002·Methods in Enzymology·David B FenskePieter R Cullis
Feb 8, 2003·Archives of Biochemistry and Biophysics·Mohamad Radwan AlmoftiHiroshi Kiwada
Apr 8, 2003·Current Medicinal Chemistry·Dan Niculescu-DuvazCaroline J Springer
Apr 8, 2003·Current Medicinal Chemistry·Céline NicolazziMichel Bessodes
Apr 8, 2003·Current Medicinal Chemistry·Dexi LiuXiang Gao
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Jul 25, 2003·International Journal of Pharmaceutics·Sanyog JainS P Vyas
Nov 13, 2003·Drug Delivery·Jaleh VarshosazAbdolhossein Rouholamini Najafabadi
Dec 20, 2003·Journal of Neuro-oncology·Jun Yoshida, Masaaki Mizuno
Apr 20, 2004·Advanced Drug Delivery Reviews·Xiaobin B Zhao, Robert J Lee
May 28, 2004·Journal of Biotechnology·Yu LiuJoo-Hwa Tay
Mar 11, 2005·Gene Therapy·P E Nielsen
Apr 26, 2005·International Journal of Pharmaceutics·Tae Woo KimSeo Young Jeong
Oct 8, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jin-Liang ChenJian-Qing Gao

❮ Previous
Next ❯

Citations

Dec 14, 2011·Molecular Pharmaceutics·Chenguang ZhouRobert J Lee
Oct 26, 2013·Nanomedicine·Orapan PaecharoenchaiRobert J Lee
Aug 23, 2011·Drug Development and Industrial Pharmacy·Lu ZhangXiao-Kun Li
Aug 31, 2012·Journal of Drug Targeting·Orapan PaecharoenchaiPraneet Opanasopit
Oct 8, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jin-Liang ChenJian-Qing Gao
Jan 22, 2011·Journal of Biomedical Materials Research. Part a·Yongzhuo HuangWenquan Liang
Jul 13, 2007·International Journal of Pharmaceutics·Jin-Liang ChenWen-Quan Liang
Feb 8, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Riccardo V D'EliaCraig W Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2022 Meta ULC. All rights reserved