Jan 1, 1984

Cationic regulation of myocardial contraction and relaxation when contraction frequency is increased

Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR
V I Kapel'ko, M S Gorina

Abstract

During augmentation of frequency of contractions or Ca2+ perfusate concentration the velocity of isotonic relaxation increased much more than the velocity or amplitude of contraction. The phenomenon of predominant activation of relaxation ( PPAR ) was less prominent at decreased Ca2+ concentration acidosis (pH 6,85), under action of calmodulin inhibitor, trifluoperazine, or replacement of Ca2+ ions by Sr2+. Diminution of Na2+ concentration to 25 mM was followed by apparent signs of cellular Ca2+--overload and elimination of PPAR . The results coincide with the suggestion that PPAR is caused by activation of calmodulin-dependent Ca2+ removal from the myoplasma and myofibrils.

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Mentioned in this Paper

PPARA
Myocardial Contraction
Ca(2+)-Transporting ATPase
PPARA wt Allele
Trifluoperazine
Peroxisome Proliferator-Activated Receptors
Calcium
Contraction (Finding)
PPARA gene
Calmodulin

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