Cationic uncouplers of oxidative phosphorylation are inducers of mitochondrial permeability transition

FEBS Letters
Yasuo ShinoharaHiroshi Terada

Abstract

To determine whether cationic uncouplers of oxidative phosphorylation induce permeability transition in mitochondria, the effects of the divalent cationic sulfhydryl cross-linker copper-o-phenanthroline (Cu(OP)2) and the cyanine dye tri-S-C4(5) on rat liver mitochondria were examined. Like Ca2+, they accelerated mitochondrial respiration with succinate and induced mitochondrial swelling when inorganic phosphate (Pi) was present in the incubation medium. The acceleration of respiration and swelling were inhibited by the SH-reagent N-ethylmaleimide, and by the specific permeability transition inhibitor cyclosporin A (CsA). In addition, these cations, like Ca2+, induced release of ADP entrapped in the mitochondrial matrix space, and the morphological change of mitochondria induced by these cations was essentially the same as that induced by Ca2+. It is concluded that the uncoupling actions of Cu(OP)2 and tri-S-C4(5) are due to induction of permeability transition in the inner mitochondrial membrane.

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Citations

Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J B CustódioL M Almeida
Oct 24, 2002·European Journal of Biochemistry·Yasuo ShinoharaHiroshi Terada
Aug 20, 2004·European Journal of Biochemistry·Takenori YamamotoYasuo Shinohara
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Oct 6, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takenori YamamotoYasuo Shinohara
Jun 25, 2003·The Journal of Toxicological Sciences·Akira UnamiYoshinobu Baba
Aug 4, 2005·Electrophoresis·Masatoshi KataokaYoshinobu Baba
Mar 2, 1999·Archives of Biochemistry and Biophysics·J WudarczykE Lenartowicz
Jul 22, 2021·Photodiagnosis and Photodynamic Therapy·Ana Flavia Gatto RaimundoRodrigo Polimeni Constantin

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