Cationizable lipid micelles as vehicles for intraarterial glioma treatment

Journal of Neuro-oncology
Juliane NguyenShailendra Joshi

Abstract

The relative abundance of anionic lipids on the surface of endothelia and on glioma cells suggests a workable strategy for selective drug delivery by utilizing cationic nanoparticles. Furthermore, the extracellular pH of gliomas is relatively acidic suggesting that tumor selectivity could be further enhanced if nanoparticles can be designed to cationize in such an environment. With these motivating hypotheses the objective of this study was to determine whether nanoparticulate (20 nm) micelles could be designed to improve their deposition within gliomas in an animal model. To test this, we performed intra-arterial injection of micelles labeled with an optically quantifiable dye. We observed significantly greater deposition (end-tissue concentration) of cationizable micelles as compared to non-ionizable micelles in the ipsilateral hemisphere of normal brains. More importantly, we noted enhanced deposition of cationizable as compared to non-ionizable micelles in glioma tissue as judged by semiquantitative fluorescence analysis. Micelles were generally able to penetrate to the core of the gliomas tested. Thus we conclude that cationizable micelles may be constructed as vehicles for facilitating glioma-selective delivery of compoun...Continue Reading

References

Sep 1, 1988·British Journal of Cancer·F Kallinowski, P Vaupel
Apr 27, 2004·Cancer Biology & Therapy·Irving J Bigio, Stephen G Bown
Jan 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maria L Garcia-MartinRobert J Gillies
Sep 12, 2006·Trends in Cell Biology·P A Janmey, P K J Kinnunen
Jul 20, 2007·Journal of Neuro-oncology·Shailendra JoshiRobert L Fine
Apr 28, 2012·Chemical Communications : Chem Comm·Colin L WalshFrancis C Szoka
Nov 9, 2012·The Journal of Membrane Biology·Izabela DobrzyńskaZbigniew A Figaszewski
Mar 26, 2014·Journal of Neuro-oncology·Shailendra JoshiRobert M Straubinger
Sep 10, 2014·Journal of Neuro-oncology·Shailendra JoshiRobert M Straubinger
Jan 13, 2015·The Journal of Membrane Biology·Izabela DobrzyńskaZbigniew A Figaszewski
May 20, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Dong Hyun JoJeong Hun Kim
Jun 26, 2015·Journal of Neuro-oncology·Shailendra JoshiJeffrey N Bruce

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Citations

Jul 20, 2016·Drug Delivery and Translational Research·Johann N R CookeShailendra Joshi
Sep 1, 2016·Journal of Neuro-oncology·Jason A EllisShailendra Joshi

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