Cats discriminate between cholecalciferol and ergocalciferol

Journal of Animal Physiology and Animal Nutrition
J G Morris

Abstract

A comparison was made of the ability of ergocalciferol and cholecalciferol to elevate plasma concentrations of vitamin D and 25-hydroxyvitamin D in cats. Cholecalciferol, given as an oral bolus in oil, resulted in a rapid elevation of plasma concentration of cholecalciferol followed by a rapid decline. In contrast, 25-hydroxyvitamin D concentration in plasma increased until day 3 after administration and remained elevated for a further 5 days. When 337 microg of both cholecalciferol and ergocalciferol in oil were given as an oral bolus to 10 cats, the peak plasma concentrations of cholecalciferol and ergocalciferol occurred at 8 or 12 h after administration. Peak concentrations of cholecalciferol were over twice those of ergocalciferol (570 +/- 80 vs. 264 +/- 42 nmol/l). The area under the curve 0-169 h for cholecalciferol was also more than twice that for ergocalciferol. When ergocalciferol and cholecalciferol were administered in a parenteral oil-based emulsion, higher concentrations of 25-hydroxyvitamin D3 than 25-hydroxyvitamin D2 were maintained in plasma. When both vitamins were included in the diet in the nutritional range, plasma concentrations of 25-hydroxyvitamin D2 were 0.68 of those of 25-hydroxyvitamin D3. Discrimi...Continue Reading

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Citations

Jan 1, 2005·Journal of the American Veterinary Medical Association·Christina M GrayLisa M Freeman
Apr 3, 2004·Journal of Animal Physiology and Animal Nutrition·J G Morris
Apr 22, 2015·Journal of Feline Medicine and Surgery·Valerie J ParkerDennis J Chew
Dec 23, 2017·JFMS Open Reports·Victoria J CrossleyNatalie C Finch
Nov 20, 2018·Journal of the American Veterinary Medical Association·Sarah A S DoddAdronie Verbrugghe
Dec 6, 2019·Journal of Animal Physiology and Animal Nutrition·Rafael V A ZafalonMarcio A Brunetto
Jan 18, 2020·PloS One·Rafael Vessecchi Amorim ZafalonMarcio Antonio Brunetto
Nov 28, 2017·Journal of Feline Medicine and Surgery·Megan C SprinkleRobert C Backus
May 17, 2017·Journal of the American Veterinary Medical Association·Valerie J ParkerDennis J Chew
Sep 19, 2020·Metabolites·Emma A HurstRichard J Mellanby
Dec 9, 2020·Metabolites·Rafael Vessecchi Amorim ZafalonMarcio Antonio Brunetto
Mar 4, 2021·Journal of Animal Physiology and Animal Nutrition·Marco FantinatiNathalie Priymenko
Mar 4, 2021·The Veterinary Clinics of North America. Small Animal Practice·Jonathan StockmanRonald Jan Corbee
Jun 25, 2021·Frontiers in Veterinary Science·Catherine E Ruggiero, Robert C Backus
Aug 24, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Janine StarzonekIngrid Vervuert

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