PMID: 1612583Jul 1, 1992Paper

Cauda equina tumor with ependymal and paraganglionic differentiation

Human Pathology
D V CaccamoJ H Garcia

Abstract

We describe the case of a 31-year-old woman who was first treated for a pigmented choroid plexus papilloma of the fourth ventricle. Ten year later, she developed a new tumor in the region of the cauda equina. This second neoplasm contained areas of papillary ependymoma that displayed phosphotungstic acid hematoxylin-positive glial fibers and immunoreactivity for glial fibrillary acidic and S-100 proteins. Areas of ependymoma merged with others that displayed the appearance of a paraganglioma, including lobules and nests of chief cells immunoreactive for neuron-specific enolase, synaptophysin, chromogranin, and serotonin. Satellite cells, but not chief cells, stained for glial fibrillary acidic and S-100 proteins. Electron microscopy showed features of both ependymal and paraganglionic differentiation, including intercellular lumina with microvilli, junctional complexes, cell processes with closely packed filaments, and dense core granules. Our case represents a rare example of a cauda equina neoplasm with simultaneous ependymal and paraganglionic differentiation. To our knowledge, this is the first described example of a tumor of this region showing features of both ependymoma and paraganglioma.

References

Jun 1, 1985·Journal of Neurosurgery·C Davis, R O Barnard
Jan 1, 1970·Acta Neuropathologica·C A Miller, R M Torack
May 1, 1968·Biological Reviews of the Cambridge Philosophical Society·G Fridberg, H A Bern

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Citations

Mar 31, 2005·Journal of Neurosurgery. Spine·Miguel Gelabert-González
Oct 23, 2013·Seminars in Diagnostic Pathology·Thomas G PapathomasArthur S Tischler
May 26, 2005·Brain Pathology·Jakob MatschkeKatrin Lamszus
Aug 4, 2004·Annals of Diagnostic Pathology·Richard A PraysonMark Luciano
May 24, 2006·Acta Neuropathologica·Julia KeithLee-Cyn Ang
Mar 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J BakB Spännare
Sep 1, 1996·The American Journal of Surgical Pathology·N ZecD C Anthony
Jan 1, 1996·Ultrastructural Pathology·G W MierauE N Orsini
Aug 25, 2001·Archives of Pathology & Laboratory Medicine·C E FullerR Schelper

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