Caudate nucleus is critically involved in trace eyeblink conditioning.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Luke C Flores, J F Disterhoft

Abstract

The basal ganglia are a collection of brain regions involved with motor planning and initiation. The major site of cortical and thalamic input into the basal ganglia network is the striatum, which includes a differentiated caudate nucleus (CN) and the putamen in rabbits. Trace eyeblink conditioning (EBC) is a forebrain-dependent associative learning task in which a stimulus-free time interval separates the presentation of a behaviorally neutral conditioned stimulus (CS) and a behaviorally salient unconditioned stimulus. We investigated whether the CN is essential for acquisition of trace EBC and whether learning-related changes in neuronal activity occur in the caudate nucleus during trace EBC. Bilateral lesions of the CN in rabbits prevent acquisition of trace EBC. In separate cohorts of rabbits, single-unit recordings showed that medium spiny neurons from regions shown to be critical by lesions display strong responses to the CS, especially in the initial days of training before acquisition. Cholinergic interneurons, or tonically active neurons, become responsive to the CS and show dramatic firing rate changes during the trace interval after learning criterion has been met. These data demonstrate that the CN is required for a...Continue Reading

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Citations

May 21, 2010·Journal of Neurophysiology·Brian E KalmbachMichael D Mauk
Jun 15, 2012·Journal of Neurophysiology·Rebekah L WardJohn F Disterhoft
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke C Flores, John F Disterhoft
Feb 15, 2011·Behavioural Brain Research·Lianne RobinsonGernot Riedel
Nov 30, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jarid GoodmanMark G Packard
Oct 25, 2016·Physiology & Behavior·Daniil P AksenovAlice M Wyrwicz

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