Caught between a "Rho" and a hard place: are CCN1/CYR61 and CCN2/CTGF the arbiters of microvascular stiffness?

Journal of Cell Communication and Signaling
Brahim Chaqour

Abstract

The extracellular matrix (ECM) is a deformable dynamic structure that dictates the behavior, function and integrity of blood vessels. The composition, density, chemistry and architecture of major globular and fibrillar proteins of the matrisome regulate the mechanical properties of the vasculature (i.e., stiffness/compliance). ECM proteins are linked via integrins to a protein adhesome directly connected to the actin cytoskeleton and various downstream signaling pathways that enable the cells to respond to external stimuli in a coordinated manner and maintain optimal tissue stiffness. However, cardiovascular risk factors such as diabetes, dyslipidemia, hypertension, ischemia and aging compromise the mechanical balance of the vascular wall. Stiffening of large blood vessels is associated with well-known qualitative and quantitative changes of fibrillar and fibrous macromolecules of the vascular matrisome. However, the mechanical properties of the thin-walled microvasculature are essentially defined by components of the subendothelial matrix. Cellular communication network (CCN) 1 and 2 proteins (aka Cyr61 and CTGF, respectively) of the CCN protein family localize in and act on the pericellular matrix of microvessels and constitu...Continue Reading

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Citations

Mar 5, 2020·American Journal of Physiology. Cell Physiology·Andrew Leask
Jul 27, 2020·Journal of Cell Communication and Signaling·Andrew Leask
Jan 8, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Andrew Leask
Jan 12, 2021·Journal of Cell Communication and Signaling·Roos J LeguitRoel Goldschmeding
Jan 6, 2021·Journal of Cell Communication and Signaling·Xu Shi-WenAndrew Leask
Mar 5, 2021·The International Journal of Biochemistry & Cell Biology·Angela Y Y TamDavid J Abraham
Jun 3, 2021·International Journal of Molecular Sciences·Daniela L RebolledoEnrique Brandan
Aug 31, 2021·Frontiers in Cardiovascular Medicine·Haicheng LiYanming Chen
Oct 7, 2021·Journal of Cell Communication and Signaling·Viktor Zaykov, Brahim Chaqour

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Methods Mentioned

BETA
biopsies
GTPases
GTPase

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