Causal associations between body mass index and mental health: a Mendelian randomisation study

Journal of Epidemiology and Community Health
Nina van den BroekJacqueline M Vink

Abstract

Body mass index (BMI) is correlated negatively with subjective well-being and positively with depressive symptoms. Whether these associations reflect causal effects is unclear. We examined bidirectional, causal effects between BMI and mental health with Mendelian randomisation using summary-level data from published genome-wide association studies (BMI: n=339 224; subjective well-being: n=204 966; depressive symptoms: n=161 460). Genetic variants robustly related to the exposure variable acted as instrumental variable to estimate causal effects. We combined estimates of individual genetic variants with inverse-variance weighted meta-analysis, weighted median regression and MR-Egger regression. There was evidence for a causal, increasing effect of BMI on depressive symptoms and suggestive evidence for a decreasing effect of BMI on subjective well-being. We found no evidence for causality in the other direction. This study provides support for a higher BMI causing poorer mental health. Further research should corroborate these findings and explore mechanisms underlying this potential causality.

References

Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Dec 18, 2010·Neuromolecular Medicine·Joanna K SoczynskaRoger S McIntyre
Mar 19, 2013·BMC Public Health·Milla S LinnaAila Rissanen
May 9, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Chi-Fa HungPeter McGuffin
Feb 7, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Stefan WalterM Maria Glymour
Feb 13, 2015·Nature·Adam E LockeElizabeth K Speliotes
Mar 17, 2015·European Journal of Epidemiology·Stephen BurgessUNKNOWN EPIC- InterAct Consortium
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Feb 7, 2016·The Lancet. Psychiatry·Daniel VigoRifat Atun
Sep 8, 2016·Scientific Reports·Fernando Pires HartwigBernardo Lessa Horta
Apr 11, 2017·Journal of the American College of Nutrition·Emile Pereira-MirandaMônica L P Santana
Jun 13, 2017·The New England Journal of Medicine·UNKNOWN GBD 2015 Obesity CollaboratorsChristopher J L Murray

❮ Previous
Next ❯

Citations

Apr 16, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Uku VainikRené Mõttus
Oct 1, 2019·Expert Opinion on Drug Safety·Wade MarteeneDan Siskind
May 20, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hilde de KluiverBrenda W J H Penninx
Aug 23, 2019·Translational Psychiatry·Hilde de KluiverBrenda W J H Penninx
Sep 14, 2019·Human Molecular Genetics·Abdel AbdellaouiDorret I Boomsma
Aug 7, 2019·Translational Psychiatry·Maria S SpeedSøren D Østergaard
Feb 20, 2021·Community Mental Health Journal·Jessica L AdameTyrone C Cheng
Apr 30, 2021·Acta Psychiatrica Scandinavica·Hilde de KluiverBrenda W J H Penninx

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.