Causal Interactions Within a Frontal-Cingulate-Parietal Network During Cognitive Control: Convergent Evidence from a Multisite-Multitask Investigation

Cerebral Cortex
Weidong CaiVinod Menon

Abstract

Cognitive control plays an important role in goal-directed behavior, but dynamic brain mechanisms underlying it are poorly understood. Here, using multisite fMRI data from over 100 participants, we investigate causal interactions in three cognitive control tasks within a core Frontal-Cingulate-Parietal network. We found significant causal influences from anterior insula (AI) to dorsal anterior cingulate cortex (dACC) in all three tasks. The AI exhibited greater net causal outflow than any other node in the network. Importantly, a similar pattern of causal interactions was uncovered by two different computational methods for causal analysis. Furthermore, the strength of causal interaction from AI to dACC was greater on high, compared with low, cognitive control trials and was significantly correlated with individual differences in cognitive control abilities. These results emphasize the importance of the AI in cognitive control and highlight its role as a causal hub in the Frontal-Cingulate-Parietal network. Our results further suggest that causal signaling between the AI and dACC plays a fundamental role in implementing cognitive control and are consistent with a two-stage cognitive control model in which the AI first detects e...Continue Reading

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Citations

Feb 3, 2016·Alcoholism, Clinical and Experimental Research·Sien HuChiang-Shan R Li
Oct 12, 2015·Social Cognitive and Affective Neuroscience·Paola OdriozolaVinod Menon
Aug 24, 2016·Journal of Psychiatric Research·Lisa M McTeagueAmit Etkin
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Aug 1, 2019·Cerebral Cortex·Jessica B GiraultJohn H Gilmore
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Feb 2, 2021·The American Journal of Psychiatry·Vinod Menon
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Apr 18, 2021·Cognitive, Affective & Behavioral Neuroscience·Xiaotong WenXia Wu
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Jun 9, 2021·Cognitive, Affective & Behavioral Neuroscience·Xiaotong WenXia Wu
Aug 6, 2021·Scientific Reports·Chia-Wei LiDanchi Tan
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vinod Menon, Mark D'Esposito
Mar 1, 2018·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Weidong CaiVinod Menon

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