Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.

Cell Metabolism
Fabien DucrocqPierre Trifilieff

Abstract

Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.

References

Aug 5, 2000·Science·K PalczewskiM Miyano
Oct 23, 2001·Genesis : the Journal of Genetics and Development·E CasanovaG Schütz
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 26, 2003·The American Journal of Psychiatry·Simona Noaghiul, Joseph R Hibbeln
Dec 6, 2003·Learning & Memory·Gaël Daoudal, Dominique Debanne
Aug 4, 2004·Journal of Neurochemistry·Frances Calderon, Hee-Yong Kim
Nov 24, 2004·Progress in Retinal and Eye Research·John Paul SanGiovanni, Emily Y Chew
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alan GrossfieldMichael C Pitman
Sep 9, 2006·The Journal of Biological Chemistry·Olivier SoubiasKlaus Gawrisch
Sep 12, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvie Chalon
Jan 24, 2007·Neuroscience Letters·Barbara S BeltzDavid C Sandeman
Dec 1, 2007·The Journal of Physiology·Emilie Campanac, Dominique Debanne
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jesus Bertran-GonzalezJean-Antoine Girault
Jun 20, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S NadalinA Buretić-Tomljanović
Oct 24, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dara M CannonWayne C Drevets
May 5, 2009·The American Journal of Psychiatry·Diego A PizzagalliMaurizio Fava
Jun 26, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yoshimi IwayamaTakeo Yoshikawa
Sep 22, 2009·Journal of Psychiatric Research·Miki IgarashiJagadeesh S Rao
Jan 12, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sarah M ConklinJeffrey K Yao
Feb 1, 2011·Nature Neuroscience·Mathieu LafourcadeOlivier J Manzoni
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Aug 17, 2011·Bipolar Disorders·Amit AnandKarmen K Yoder
Sep 10, 2011·The Journal of Clinical Psychiatry·Jerome SarrisIsaac Schweitzer
Sep 24, 2011·The Journal of Clinical Psychiatry·M Elizabeth SubletteJ John Mann
Mar 13, 2012·The American Journal of Psychiatry·Gregory P Strauss, James M Gold
Apr 3, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J V PottalaW S Harris
Jul 11, 2012·Journal of Abnormal Psychology·Michael T TreadwayDavid H Zald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.