Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Yang-Ching ChenYungling L Lee

Abstract

Obesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the causal direction of the relationship between adiposity and asthma using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. We used data from the Taiwan Children Health Study with 24 body mass index (BMI)-single-nucleotide polymorphisms (SNPs, combined into a weighted allelic score) and 16 asthma-SNPs (combined into two weighted allelic scores, separately for asthma inflammatory and antioxidative genes) to yield genetic IVs for adiposity and asthma, respectively. The weighted allele score for BMI was strongly associated with adiposity (p = 2 × 10-16) and active asthma (p = 0.03). The two-stage least square regression risk ratio (RR) for the effect of BMI on asthma was 1.04 (95% confidence interval: 1.00-1.07, p = 0.03). Although the weighted asthma genetic scores were significantly associated with asthma (p = 8.4 × 10-3), no association was seen for genetically instrumented asthma with BMI using MR. Central obesity was the most accurate predictor of asthma. Adiposity showed higher causal effects on asthma in boys and children with non-atopic asthma. Sensitivity ...Continue Reading

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Citations

Apr 22, 2019·International Journal of Epidemiology·Shujing XuDavid V Conti
May 2, 2019·Annals of the American Thoracic Society·Erick Forno
Jul 13, 2019·International Journal of Epidemiology·Rebecca C Richmond, George Davey Smith
Nov 5, 2019·American Journal of Respiratory and Critical Care Medicine·Erick Forno
Mar 4, 2020·International Journal of Environmental Research and Public Health·Lijuan LaiYajun Chen
Dec 4, 2019·Pediatric Research·Hsien-Yu FanYang-Ching Chen
Sep 5, 2020·Human Molecular Genetics·Diana L Cousminer, Rachel M Freathy
Jan 11, 2020·Frontiers in Pediatrics·Eva Morales, David Duffy
Oct 15, 2020·Journal of Epidemiology and Community Health·Shiu Lun Au YeungC Mary Schooling
Nov 11, 2020·American Journal of Epidemiology·Danielle R StevensPauline Mendola
Dec 3, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yang-Ching ChenYungling L Lee

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Methods Mentioned

BETA
genotyping

Software Mentioned

Plink
R3
Stata

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