Causative organisms in microbial keratitis, their sensitivity pattern and treatment outcome in western Nepal

Nepalese Journal of Ophthalmology : a Biannual Peer-reviewed Academic Journal of the Nepal Ophthalmic Society : NEPJOPH
K DhakhwaS Rai

Abstract

Corneal infection is one of the major causes of monocular blindness in developing countries. To determine the epidemiological characteristics, predisposing factors, microbiological pattern, sensitivity pattern and treatment outcome of microbial keratitis. A retrospective analysis of hospital records of 414 patients with diagnosed infective keratitis was done. The outcome measures were microbial isolates, their sensitivity to therapeutic agents and treatment outcome. Of the total, 312 (75.4 %) patients were farmers by profession, 138 (33.3 %) had a history of ocular trauma and 17(4.1 %) were using topical corticosteroids. Among the 138 cases of the corneal ulcer with trauma, 52 (37.68 %) had fungi isolated in culture (RR=0.54, 95% CI = 0.44 - 0.68) and 32 (23.19 %) had a bacterial growth. Cultures were positive in 300 (72.5 %) cases, having 138 (33.3 %) patients with pure fungal infection, 121 (29.2 %) with pure bacterial and 41 (9.9 %) with mixed infection. Fusarium spp was the most common fungal pathogen while Staphylococcus epidermidis was the commonest bacterial isolate. The most sensitive antibiotics for the Gram positive bacteria was cephazolin (84.92 %), while for Gram negative, ciprofloxacin and ofloxacin were the most e...Continue Reading

Citations

Oct 10, 2015·Mycoses·Ushana Shrestha Khwakhali, David W Denning
Aug 22, 2014·The British Journal of Ophthalmology·Prajna LalithaJeremy D Keenan
Jun 25, 2015·Asia-Pacific Journal of Ophthalmology·Bibhudutta RautarayaSrikant K Sahu
Dec 22, 2019·Medicine·Tahra AlMahmoudFikri M Abu-Zidan

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