Cause of Death in Patients with Reduced Kidney Function

Journal of the American Society of Nephrology : JASN
Stephanie ThompsonAlberta Kidney Disease Network

Abstract

Information on common causes of death in people with CKD is limited. We hypothesized that, as eGFR declines, cardiovascular mortality and mortality from infection account for increasing proportions of deaths. We calculated eGFR using the CKD Epidemiology Collaboration equation for residents of Alberta, Canada who died between 2002 and 2009. We used multinomial logistic regression to estimate unadjusted and age- and sex-adjusted differences in the proportions of deaths from each cause according to the severity of CKD. Cause of death was classified as cardiovascular, infection, cancer, other, or not reported using International Classification of Diseases codes. Among 81,064 deaths, the most common cause was cancer (31.9%) followed by cardiovascular disease (30.2%). The most common cause of death for those with eGFR≥60 ml/min per 1.73 m(2) and no proteinuria was cancer (38.1%); the most common cause of death for those with eGFR<60 ml/min per 1.73 m(2) was cardiovascular disease. The unadjusted proportion of patients who died from cardiovascular disease increased as eGFR decreased (20.7%, 36.8%, 41.2%, and 43.7% of patients with eGFR≥60 [with proteinuria], 45-59.9, 30-44.9, and 15-29.9 ml/min per 1.73 m(2), respectively). The propo...Continue Reading

References

Feb 15, 2001·Archives of Internal Medicine·A E Smith Sehdev, G M Hutchins
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Berthus G LoefCoen A Stegeman
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Gérard M LondonFabien Métivier
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Linda F FriedAnne B Newman
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Dec 19, 2006·BMC Health Services Research·Lawrence SoHude Quan
Nov 30, 2007·American Journal of Nephrology·Michel ChoncholNancy R Kressin
Feb 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles A HerzogDavid T Gilbertson
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 19, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew T JamesUNKNOWN Alberta Kidney Disease Network
May 30, 2009·Journal of the American Society of Nephrology : JASN·Masahide MizobuchiEduardo Slatopolsky
Oct 21, 2009·BMC Nephrology·Brenda R HemmelgarnMarcello Tonelli
Oct 28, 2009·Hypertension·Hude QuanUNKNOWN Hypertension Outcome and Surveillance Team of the Canadian Hypertension Education Programs
Feb 4, 2010·JAMA : the Journal of the American Medical Association·Brenda R HemmelgarnUNKNOWN Alberta Kidney Disease Network
Feb 17, 2010·International Journal of Health Geographics·Henry E WangGeorge Howard
Oct 21, 2010·Circulation. Arrhythmia and Electrophysiology·Palaniappan Saravanan, Neil C Davidson
Aug 24, 2011·American Journal of Nephrology·Henry E WangPaul Muntner
Oct 14, 2011·Kidney International·William G CouserMarcello Tonelli
Nov 8, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aminu BelloUNKNOWN Alberta Kidney Disease Network

❮ Previous
Next ❯

Citations

Feb 18, 2016·Kidney International·Sankar D NavaneethanJoseph V Nally
Mar 1, 2016·Frontiers in Immunology·Heidi Noels, Jürgen Bernhagen
Oct 19, 2016·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Piergiorgio BolascoKamyar Kalantar-Zadeh
Aug 2, 2016·The Lancet. Diabetes & Endocrinology·UNKNOWN Cholesterol Treatment Trialists' (CTT) CollaborationColin Baigent
Sep 24, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan RossaintAlexander Zarbock
Jun 3, 2017·American Journal of Human Genetics·Yi-An KoKatalin Susztak
Aug 7, 2017·Heart·Iryna SchlackowUNKNOWN SHARP Collaborative Group
Apr 27, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guy H Neild
Aug 26, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Archna BajajUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators*
Oct 13, 2017·QJM : Monthly Journal of the Association of Physicians·A M PriceJ N Townend
Nov 10, 2018·Statistical Methods in Medical Research·M H ElsensohnR Ecochard
Apr 27, 2018·Journal of the American Society of Nephrology : JASN·Valeria M SaglimbeneGiovanni F M Strippoli
Jun 6, 2015·Journal of the American Society of Nephrology : JASN·Germaine Wong, Amit X Garg
Mar 10, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Milica BozicUNKNOWN NEFRONA investigators
Dec 15, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francis VerbekeGriet Glorieux
Nov 2, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Aslam AmodUNKNOWN DEVOTE Study Group
Feb 7, 2020·Annals of Clinical Biochemistry·R A JonesUNKNOWN eGFR-C Study Group
Jun 7, 2019·BMC Nephrology·Marcello TonelliUNKNOWN Alberta Kidney Disease Network
Mar 30, 2016·Current Opinion in Nephrology and Hypertension·Maneesh Sud, David M J Naimark
Oct 24, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Aruna ArjunanJo Taylor
May 19, 2016·Current Opinion in Nephrology and Hypertension·Theresa ErmerFelix Knauf
Feb 16, 2016·The Journal of Clinical Investigation·Jan RossaintAlexander Zarbock
Jul 31, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guobin SuCecilia Stålsby Lundborg
Jun 21, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guobin SuJuan Jesus Carrero
Nov 9, 2019·Toxins·Isabel VogtMaren Leifheit-Nestler
Mar 28, 2020·Journal of the American Heart Association·Jonathan P LawCharles J Ferro
Jul 9, 2020·Toxins·Gerald Cohen
May 10, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Ping LiSushrut S Waikar
Dec 13, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Andreas PaschJuergen Floege

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Tanvir C TurinBrenda Hemmelgarn
Clinical Journal of the American Society of Nephrology : CJASN
Sankar D NavaneethanJoseph V Nally
Journal of the American Society of Nephrology : JASN
Stephen ZewingerDanilo Fliser
Clinical Journal of the American Society of Nephrology : CJASN
Neha GargSankar D Navaneethan
© 2022 Meta ULC. All rights reserved