Cause of residual hypertension after adrenalectomy in patients with primary aldosteronism

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Y HoritaS Takishita

Abstract

The cause of residual hypertension after adrenalectomy for primary aldosteronism (PA) is unknown. The purpose of this study is to investigate the characteristic pathological kidney features associated with PA. Between 1977 and 1999 at our hospital, 26 patients with PA caused by a unilateral adrenal cortical adenoma (Conn's syndrome) underwent unilateral adrenalectomy with concurrent open-wedge renal biopsy. Patients were categorized into two groups: (1) those with normotension with diastolic blood pressure less than 90 mm Hg who were not administered antihypertensive drugs, and (2) those with residual hypertension with diastolic blood pressure of 90 mm Hg or greater who were administered medication for 6 months after surgery. Thirteen patients were cured of hypertension postoperatively, and 12 patients were administered antihypertensive medications. Glomerulosclerosis, renal arteriolosclerosis, and preoperative left ventricular mass (LVM) index were worse in the group with residual hypertension than in that with normotension (17.8% +/- 7.8% versus 9.6% +/- 3.8%; P = 0.01; 2.5 +/- 0.5 versus 1.6 +/- 0.4, Bader's grade; P = 0.005; and 165 +/- 31 versus 139 +/- 24 g/m(2); P = 0.02, respectively). Severity of tubulointerstitial inj...Continue Reading

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Citations

Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Terry Ting-Yu ChiouChien-Te Lee
Nov 2, 2011·Endocrine·Norlela Sukor
Nov 30, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Takanobu UtsumiTomohiko Ichikawa
Jan 22, 2011·European Journal of Clinical Investigation·Yen-Hung LinUNKNOWN TAIPAI study group
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuji FukudomeMasatoshi Fujishima
Feb 25, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vin-Cent WuUNKNOWN TAIPAI Study Group
Jun 4, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wen-Fang ChiangShih-Hua Lin
Nov 24, 2016·The Journal of Clinical Hypertension·Gudbjörg JonsdottirHelga Agusta Sigurjonsdottir
May 18, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Che-Wei LiaoUNKNOWN TAIPAI Study Group
May 18, 2004·The Surgical Clinics of North America·Maha Al Fehaily, Quan-Yang Duh
Jul 25, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN TAIPAI Study GroupKwan-Dun Wu
Aug 20, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yen-Hung LinUNKNOWN TAIPAI study group
Jun 15, 2007·Journal of Hypertension·Marileda NovelloLeonardo A Sechi
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Jun 13, 2012·Journal of Hypertension·Yen-Hung LinUNKNOWN TAIPAI Study Group
Jul 13, 2019·Nature Reviews. Nephrology·Yuka SatoRichard J Johnson
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Vin-Cent WuUNKNOWN TAIPAI Study Group
Jul 18, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Chin-Chi KuoUNKNOWN TAIPAI group
Sep 29, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leonardo A Sechi, Cristiana Catena

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