Causes and empirical treatment of fever in HIV-infected adult outpatients, Abidjan, Côte d'Ivoire

AIDS
Xavier AnglaretANRS 059-Cotrimo-CI study group

Abstract

In Abidjan, HIV prevalence has been estimated at 20% in outpatients attending community clinics. Documenting causes of fever in HIV-infected adult outpatients may help to improve care in these centres with limited facilities. Prospective study. We describe all diagnoses and treatments made during febrile episodes in HIV-infected adults participating in the ANRS 059 trial and followed up in a dedicated outpatient centre. Causes of fever could be identified in half of the 269 febrile episodes. Bacterial diseases were the leading identified cause of fever in all CD4 cell count strata (53, 56 and 43% of identified causes in episodes with CD4 count < 200 x 106/l, 200-499 x 106/l, and >or= 500 x 106/l, respectively), followed by malaria (5, 22, and 38%, respectively). Among febrile bacterial diseases, respiratory tract infections and enteritis accounted for 62% of organ involvement, and Streptococcus pneumoniae and non-typhi Salmonella represented 69% of isolated bacterial strains. In these bacterial episodes, an early empirical antibacterial treatment was associated with shorter duration of hospitalization and fever. In the 19 episodes leading to death (7%), the two leading diagnoses were atypical mycobacteriosis (26%) and acute une...Continue Reading

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Citations

Jan 11, 2008·AIDS Research and Human Retroviruses·Catherine SeylerXavier Anglaret
Apr 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen H KeddyUNKNOWN Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA)
Apr 5, 2005·American Journal of Respiratory and Critical Care Medicine·Catherine SeylerXavier Anglaret
Feb 20, 2007·Bulletin of the World Health Organization·Albert MingaUNKNOWN ANRS 1220 Study Group
Jan 1, 2006·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·W Mamidou KonéM Dosso
Apr 10, 2014·Journal of the International AIDS Society·Charlotte LewdenUNKNOWN IeDEA West Africa Collaboration
Jul 14, 2007·Médecine et maladies infectieuses·G Martin-BlondelB Marchou
Dec 2, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ibironke O OlofinWafaie W Fawzi
Oct 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Paula E BrentlingerTroy D Moon
Jun 10, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christine DanelXavier Anglaret
Jan 28, 2006·The Lancet Infectious Diseases·Paula E BrentlingerMark A Micek
Sep 9, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N Boillat-BlancoV D'Acremont
Jun 28, 2011·The Lancet Infectious Diseases·Clara FlateauGilles Pialoux

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