Causes and predictive factors of mortality in a cohort of patients with hepatitis C virus-related cryoglobulinemic vasculitis treated with antiviral therapy

The Journal of Rheumatology
Dan-Avi LandauP Cacoub

Abstract

Hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) vasculitis is an autoimmune disorder with significant morbidity and mortality. Renal involvement was associated with an increased mortality, and was the most common cause of death; these data were obtained before effective antiviral treatment was available. We studied causes of death and predictive factors in patients with HCV-associated MC vasculitis treated with antivirals. Case histories of 85 patients with HCV-associated MC vasculitis treated in a single center between 1990 and 2006 were retrospectively reviewed. Prognostic factors affecting mortality were studied by comparing 23 patients who died with 62 survivors, using the Cox model regression analysis. The most common cause of death was infection, accounting for 34.7%, followed by endstage liver disease in 30.4% (including 4 patients with hepatocellular carcinoma), and cardiovascular disease in 17.4% of patients. Endstage renal disease accounted for only 8.7% of deaths, as did central nervous system vasculitis and nonhepatic malignancy. Increased mortality was strongly associated with immunosuppressive treatment [hazard ratio (HR) 6.51, 95% CI 2.75-15.37], cutaneous ulcers (HR 5.37, 95% CI 1.79-16.14), and r...Continue Reading

References

May 1, 1992·Annals of the Rheumatic Diseases·B GodeauJ R Le Gall
Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Nov 1, 1974·The American Journal of Medicine·J C BrouetM Seligmann
Aug 1, 1980·The American Journal of Medicine·P D GorevicE C Franklin
Dec 1, 1995·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·L F Callahan, T Pincus
Apr 17, 2001·Gut·A H Mohsen, UNKNOWN Trent HCV Study Group
Jan 16, 2002·Current Opinion in Rheumatology·Patrice CacoubLaurent Alric
Dec 17, 2002·Arthritis and Rheumatism·Patrice CacoubJean-Charles Piette
Feb 1, 2003·Blood·Francesco ZajaGianfranco Ferraccioli
May 15, 2003·Current Rheumatology Reports·Dimitrios Vassilopoulos, Leonard H Calabrese
Aug 15, 2003·Leukemia & Lymphoma·Wen-Kai Weng, Shoshana Levy
Dec 3, 2003·Annals of the Rheumatic Diseases·P LamprechtW L Gross
Feb 12, 2004·Arthritis and Rheumatism·Dominique BlignyLoïc Guillevin
Jun 11, 2004·Seminars in Arthritis and Rheumatism·Clodoveo FerriAnna Linda Zignego
Oct 21, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dario RoccatelloLuigi Massimino Sena
Mar 29, 2005·The Lancet Infectious Diseases·Domenico Sansonno, Franco Dammacco
Jun 18, 2005·Arthritis Research & Therapy·Ann Mohrbacher
Sep 26, 2006·Seminars in Arthritis and Rheumatism·Manuel Ramos-CasalsJosep Font
Jul 7, 2007·Leukemia & Lymphoma·Sercan AksoyIbrahim Barista
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Robert N Foley, Allan J Collins
Aug 19, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marcella VisentiniMilvia Casato
Jan 29, 2008·European Journal of Haematology·Omer DizdarIbrahim Barista
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Dario RoccatelloLuigi M Sena

❮ Previous
Next ❯

Citations

Sep 13, 2013·The New England Journal of Medicine·Franco Dammacco, Domenico Sansonno
Feb 25, 2011·Current Opinion in Rheumatology·Cees G M Kallenberg
Nov 18, 2014·Rheumatic Diseases Clinics of North America·Daniela GhetieCailin H Sibley
Apr 8, 2014·Neurologic Clinics·David S Younger
Mar 15, 2011·Arthritis and Rheumatism·Benjamin TerrierPatrice Cacoub
Apr 17, 2013·Journal of Medical Virology·Fabrizio FabriziPiergiorgio Messa
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Aug 29, 2012·Clinical & Developmental Immunology·Laurent ChicheNoemie Jourde
Dec 31, 2014·Seminars in Arthritis and Rheumatism·Dilia GiuggioliClodoveo Ferri
Sep 20, 2016·Journal of Hepatology·Patrice CacoubClodoveo Ferri
Oct 12, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martín BonacciJosé Hernández-Rodríguez
Apr 7, 2016·PloS One·Amandine CollinUNKNOWN ANRS CO3 Aquitaine Cohort Study Group
Apr 4, 2017·Current Opinion in Rheumatology·Anne C DesboisPatrice Cacoub
May 16, 2014·Current Opinion in Rheumatology·Mirjan M van TimmerenCees G M Kallenberg
Mar 3, 2015·World Journal of Hepatology·Chalermrat BunchorntavakulDisaya Chavalitdhamrong
Aug 4, 2018·Nature Reviews. Disease Primers·Dario RoccatelloClodoveo Ferri
Dec 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN AASLD-IDSA Hepatitis C Guidance Panel
Jun 21, 2017·Terapevticheskiĭ arkhiv·T M IgnatovaN A Mukhin
Sep 18, 2015·World Journal of Hepatology·Javier Ampuero, Manuel Romero-Gómez
Nov 2, 2016·Blood·Eli MuchtarMorie A Gertz
Nov 16, 2018·Clinical and Experimental Medicine·Franco DammaccoVito Racanelli
Nov 20, 2019·Current Rheumatology Reports·Alejandro FuentesPaula I Burgos
Feb 1, 2020·Current Vascular Pharmacology·Stergios SoulaidopoulosTheodoros Dimitroulas
Jul 4, 2020·Cardiology in Review·Michael BrokerWilliam H Frishman
Jun 11, 2020·Seminars in Arthritis and Rheumatism·Gonçalo BoletoDavid Saadoun
Dec 4, 2020·Clinics and Research in Hepatology and Gastroenterology·Gonçalo BoletoPatrice Cacoub

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ute EisenbergerLaure-Hélène Noël
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S A BakkalogluT Ozer
© 2021 Meta ULC. All rights reserved