Causes and predictors of mortality in hospitalized lupus patient in Sarawak General Hospital, Malaysia

Lupus
Cheng Lay Teh, G R Ling

Abstract

Systemic lupus erythematosus (SLE) is a serious autoimmune disease that can be life threatening and fatal if left untreated. Causes and prognostic indicators of death in SLE have been well studied in developed countries but lacking in developing countries. We aimed to investigate the causes of mortality in hospitalized patients with SLE and determine the prognostic indicators of mortality during hospitalization in our center. All SLE patients who were admitted to Sarawak General Hospital from January 1, 2006 to December 31, 2010, were followed up in a prospective study using a standard protocol. Demographic data, clinical features, disease activities and damage indices were collected. Logistic regression and Cox regression analysis were used to determine the prognostic indicators of mortality in our patients. There were a total of 251 patients in our study, with the female to male ratio 10 to 1. Our study patients were of multiethnic origins. They had a mean age of 30.5 ± 12.2 years and a mean duration of illness of 36.5 ± 51.6 months. The main involvements were hematologic (73.3%), renal (70.9%) and mucocutaneous (67.3%). There were 26 deaths (10.4%), with the main causes being: infection and flare (50%), infection alone (19%)...Continue Reading

References

Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Apr 18, 2000·Rheumatic Diseases Clinics of North America·I BruceM B Urowitz
May 25, 2006·Medicine·Nuntana KasitanonMichelle Petri
Jul 27, 2006·Arthritis and Rheumatism·S BernatskyR Ramsey-Goldman
Sep 17, 2008·The Journal of Rheumatology·M B UrowitzV T Farewell
Oct 16, 2010·Lupus·M Y Mok, W L Li

Citations

Sep 4, 2014·Autoimmunity Reviews·Eyal ZimlichmanGisele Zandman-Goddard
Oct 24, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Eduardo Martín NaresHeriberto Ontiveros Mercado
Oct 24, 2014·Rheumatology·Nuntana KasitanonWorawit Louthrenoo
Jul 6, 2016·Clinical Rheumatology·Emilio Andres BuschiazzoGustavo Citera
Dec 22, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Lifen WuLu Gong
Mar 9, 2020·Rheumatology International·Marwan H AdwanKhader N Mustafa

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.