Causes of acute undifferentiated fever and the utility of biomarkers in Chiangrai, northern Thailand

PLoS Neglected Tropical Diseases
Tri WangrangsimakulDaniel H Paris

Abstract

Tropical infectious diseases like dengue, scrub typhus, murine typhus, leptospirosis, and enteric fever continue to contribute substantially to the febrile disease burden throughout Southeast Asia while malaria is declining. Recently, there has been increasing focus on biomarkers (i.e. C-reactive protein (CRP) and procalcitonin) in delineating bacterial from viral infections. A prospective observational study was performed to investigate the causes of acute undifferentiated fever (AUF) in adults admitted to Chiangrai Prachanukroh hospital, northern Thailand, which included an evaluation of CRP and procalcitonin as diagnostic tools. In total, 200 patients with AUF were recruited. Scrub typhus was the leading bacterial cause of AUF (45/200, 22.5%) followed by leptospirosis (15/200, 7.5%) and murine typhus (7/200, 3.5%), while dengue was the leading viral cause (23/200, 11.5%). Bloodstream infections contributed to 7/200 (3.5%) of the study cohort. There were 9 deaths during this study (4.5%): 3 cases of scrub typhus, 2 with septicaemia (Talaromyces marneffei and Haemophilus influenzae), and 4 of unknown aetiologies. Rickettsioses, leptospirosis and culture-attributed bacterial infections, received a combination of 3rd generation ...Continue Reading

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Citations

Feb 6, 2019·Tropical Medicine and Infectious Disease·Rajendra GautamJeevan Bahadur Sherchand
Mar 14, 2019·Journal of the Pediatric Infectious Diseases Society·Tri WangrangsimakulDaniel H Paris
Mar 13, 2019·The American Journal of Tropical Medicine and Hygiene·Meghna PhanichkrivalkosilStuart D Blacksell
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Jan 12, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Chien-Chang LeePhilipp Schuetz
Apr 15, 2020·PLoS Neglected Tropical Diseases·Tri WangrangsimakulSerge Morand
Aug 4, 2020·Vector Borne and Zoonotic Diseases·Sirirat PhomjareetAllen L Richards
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Oct 2, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Akelew YibeltalCnops Lieselotte
Dec 4, 2021·Frontiers in Public Health·Xianghong LiuZhijuan Lu

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Methods Mentioned

BETA
ELISA
PCR
ELISAs

Software Mentioned

Salford Predictive Modeler Software Suite
STATA

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